The Second Clinical Medical College, Lanzhou University, No. 222 Tianshui South Road, Cheng-Guan District, Lanzhou 730030, China.
The First Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
Int J Environ Res Public Health. 2023 Jan 14;20(2):1552. doi: 10.3390/ijerph20021552.
Pancreatic cancer poses a serious medical problem worldwide. Studies have reported the relationship between smoking and cancer. This study aimed to evaluate the burden of pancreatic cancer attributable to smoking and its global, regional and national trends, patterns and alterations from 1990 to 2019.
Data were extracted from the Global Health Data Exchange query tool, including deaths, disability-adjusted life-years (DALYs) and age-standardized rates (ASRs). Measures were stratified by sex, age, region, country/territory and sociodemographic index (SDI). We used Joinpoint regression to determine the secular trend of ASRs by calculating the average annual percentage change (AAPC).
In 2019, smoking risk-related deaths and DALYs accounted for 21.3% and 21.1% of global pancreatic cancer, respectively. There were 113,384 (95% UI 98,830 to 128,466) deaths of smoking-attributable pancreatic cancer worldwide in 2019, of which 64.1% were in males. The disease burden was higher in males than in females. High-income regions or large population regions had the higher disease burden. East Asia carried the highest number of smoking-attributable pancreatic cancer deaths and DALYs. The Caribbean had the fastest increasing rate (AAPC = 3.849, 95% CI 3.310 to 4.391) of age-standardized death rate over the past 30 years. In 2019, China had the highest number of deaths, which was followed by the USA and Japan. There was a trend of increasing ASDR along with increases in SDI.
Variations existed in the smoking risk-related pancreatic cancer burden among different sexes, age groups, regions and countries/territories. The burden of smoking-attributable pancreatic cancer should be considered an important health issue. Future strategies should include comprehensive policies to control tobacco use.
胰腺癌是全球严重的医学问题。研究报告了吸烟与癌症之间的关系。本研究旨在评估吸烟导致的胰腺癌负担及其全球、区域和国家趋势、模式和变化，时间范围为 1990 年至 2019 年。
从全球健康数据交换查询工具中提取数据，包括死亡人数、残疾调整生命年（DALY）和年龄标准化率（ASR）。这些指标按性别、年龄、地区、国家/地区和社会人口指数（SDI）进行分层。我们使用 Joinpoint 回归来确定 ASR 的时间趋势，通过计算平均年度百分比变化（AAPC）来实现。
2019 年，与吸烟相关的死亡人数和 DALY 分别占全球胰腺癌的 21.3%和 21.1%。2019 年全球有 113384 例（95%置信区间为 98830 至 128466）归因于吸烟的胰腺癌死亡，其中 64.1%发生在男性。男性的疾病负担高于女性。高收入地区或人口较多的地区疾病负担较高。东亚地区归因于吸烟的胰腺癌死亡人数和 DALY 最多。加勒比地区的年龄标准化死亡率增长最快（AAPC=3.849，95%CI 3.310 至 4.391）。2019 年，中国的死亡人数最多，其次是美国和日本。随着 SDI 的增加，ASDR 呈上升趋势。
不同性别、年龄组、地区和国家/地区之间，吸烟相关的胰腺癌负担存在差异。吸烟导致的胰腺癌负担应被视为一个重要的健康问题。未来的策略应包括控制烟草使用的综合政策。
