通过串联环丙烷开环/烯丙基化和迈克尔加成/烯丙基化反应合成 3,4-稠合吲哚。
3,4-Annulated Indoles via Tandem Cyclopropane Ring-Opening/Conia-ene and Michael Addition/Conia-ene Reactions.
机构信息
Department of Chemistry, The University of Western Ontario, London, ON N6A 5B7, Canada.
出版信息
Org Lett. 2022 Aug 5;24(30):5509-5512. doi: 10.1021/acs.orglett.2c01810. Epub 2022 Jul 21.
PMID:35862275
Abstract
4-Alkynyl indoles, when treated with a benzylidene malonate or a donor-acceptor cyclopropane in the presence of a zinc halide, furnished 3,4-hexannylated or 3,4-heptannulated products, respectively, in fair to excellent yields. The reaction proceeds via a tandem addition/Conia-ene cyclization.
摘要
4-炔基吲哚在卤化锌存在下与苯亚甲基丙二酸酯或给体-受体环丙烷反应，分别以中等到优秀的收率得到 3,4-己烷基化或 3,4-庚烷基化产物。该反应通过串联加成/Conia-ene 环化进行。
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