2-炔基吲哚的串联环丙烷开环/Conia-ene 反应：四氢咔唑的[3 + 3]环合途径。
Tandem cyclopropane ring-opening/Conia-ene reactions of 2-alkynyl indoles: a [3 + 3] annulative route to tetrahydrocarbazoles.
机构信息
Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7.
出版信息
Org Lett. 2011 Jan 21;13(2):220-3. doi: 10.1021/ol102627e. Epub 2010 Dec 16.
PMID:21162555
Abstract
A Zn(NTf(2))(2) catalyzed tandem reaction consisting of a nucelophilic ring opening of 1,1-cyclopropanediesters by 2-alkynyl indoles followed by a Conia-ene ring closure results in the efficient one-step synthesis of tetrahydrocarbazoles. The adducts may be further elaborated to carbazoles.
摘要
一种由 Zn(NTf(2))(2) 催化的串联反应，包括 1,1-环丙二酯的亲核开环和 2-炔基吲哚的 Conia-ene 环闭合，可高效一步合成四氢咔唑。这些加成物可以进一步衍生为咔唑。
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