Shandong Provincial Key Laboratory of Biochemical Engineering, College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.
Shandong Provincial Key Laboratory of Biochemical Engineering, College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.
Fish Shellfish Immunol. 2022 Aug;127:925-932. doi: 10.1016/j.fsi.2022.07.038. Epub 2022 Jul 19.
PLEKHF2 proteins are widespread in animals, but their functions and mechanisms remain poorly defined. Here we clearly demonstrate that PLEKHF2 is a newly identified present abundantly in the eggs/embryos of zebrafish. We also show that recombinant PLEKHF2 acts as a pattern recognition receptor capable of identifying the bacterial signature molecule PGN, LPS, and LTA, binding the bacteria, and functions as an antibacterial effector directly killing the bacteria. In brief, these results indicate that PLEKHF2 is an antibacterial protein, a novel role assigned to PLEKHF2 proteins.
PLEKHF2 蛋白广泛存在于动物中，但它们的功能和机制仍未得到明确界定。在这里，我们清楚地表明，PLEKHF2 是一种新发现的蛋白，在斑马鱼的卵子/胚胎中大量存在。我们还表明，重组 PLEKHF2 作为一种模式识别受体，能够识别细菌特征分子 PGN、LPS 和 LTA，结合细菌，并作为一种直接杀伤细菌的抗菌效应因子发挥作用。简而言之，这些结果表明 PLEKHF2 是一种抗菌蛋白，这是 PLEKHF2 蛋白的一个新功能。
