Hill Jeremy, Ashken Toby, West Simeon, Macfarlane Alan James Robert, El-Boghdadly Kariem, Albrecht Eric, Chin Ki Jinn, Fox Ben, Gupta Ashwani, Haskins Stephen, Haslam Nat, Hogg Rosemary Margaret Gilmore, Hormis Anil, Johnston David F, Mariano Edward R, Merjavy Peter, Moll Timothy, Parry James, Pawa Amit, Russon Kim, Sebastian Maria Paz, Turbitt Lloyd, Womack Jonathan, Chazapis Maria
Department of Anaesthetics, University College London Hospitals NHS Foundation Trust, London, UK
Department of Anaesthetics, University College London Hospitals NHS Foundation Trust, London, UK.
Reg Anesth Pain Med. 2022 Jul 21. doi: 10.1136/rapm-2022-103751.
BACKGROUND/IMPORTANCE: There is heterogeneity among the outcomes used in regional anesthesia research.
We aimed to produce a core outcome set for regional anesthesia research.
We conducted a systematic review and Delphi study to develop this core outcome set. A systematic review of the literature from January 2015 to December 2019 was undertaken to generate a long list of potential outcomes to be included in the core outcome set. For each outcome found, the parameters such as the measurement scale, timing and definitions, were compiled. Regional anesthesia experts were then recruited to participate in a three-round electronic modified Delphi process with incremental thresholds to generate a core outcome set. Once the core outcomes were decided, a final Delphi survey and video conference vote was used to reach a consensus on the outcome parameters.
Two hundred and six papers were generated following the systematic review, producing a long list of 224 unique outcomes. Twenty-one international regional anesthesia experts participated in the study. Ten core outcomes were selected after three Delphi survey rounds with 13 outcome parameters reaching consensus after a final Delphi survey and video conference.
We present the first core outcome set for regional anesthesia derived by international expert consensus. These are proposed not to limit the outcomes examined in future studies, but rather to serve as a minimum core set. If adopted, this may increase the relevance of outcomes being studied, reduce selective reporting bias and increase the availability and suitability of data for meta-analysis in this area.
背景/重要性：区域麻醉研究中使用的结果存在异质性。
我们旨在制定区域麻醉研究的核心结局集。
我们进行了一项系统评价和德尔菲研究以制定此核心结局集。对2015年1月至2019年12月的文献进行系统评价，以生成可能纳入核心结局集的一长串潜在结果。对于发现的每个结果，汇编测量量表、时间和定义等参数。然后招募区域麻醉专家参与三轮电子改良德尔菲过程，设置递增阈值以生成核心结局集。一旦确定了核心结局，就通过最终的德尔菲调查和视频会议投票就结局参数达成共识。
系统评价后产生了206篇论文，生成了包含224个独特结果的一长串清单。21位国际区域麻醉专家参与了该研究。经过三轮德尔菲调查后选择了10个核心结局，经过最终的德尔菲调查和视频会议，13个结局参数达成了共识。
我们提出了首个经国际专家共识得出的区域麻醉核心结局集。提出这些并非为了限制未来研究中所考察的结果，而是作为一个最小核心集。如果采用，这可能会增加所研究结果的相关性，减少选择性报告偏倚，并提高该领域数据用于荟萃分析的可得性和适用性。
