Yuasa S, Nakao Y, Umezu K
Jpn J Pharmacol. 1987 Mar;43(3):263-6. doi: 10.1254/jjp.43.263.
Tritoqualine (TRQ) was previously reported to suppress enzyme leakage and lipid peroxidation induced by carbon tetrachloride in isolated hepatocytes. In the present study, we investigated the effect of TRQ on enzyme leakage from rat primary-cultured hepatocytes using D-galactosamine (GalN) which causes hepatic injury without lipid peroxidation. Leakage of GPT and GPT was significantly increased at 18 hr after GalN addition, being saturated at 42-50 hr. This enzyme leakage was suppressed dose-dependently by TRQ at 42 hr, but not by vitamin E. These results suggest that TRQ shows a suppressive effect on enzyme leakage from hepatocytes independently of its inhibitory action on lipid peroxidation.
先前有报道称三甲曲喹啉（TRQ）可抑制四氯化碳诱导的离体肝细胞中的酶泄漏和脂质过氧化。在本研究中，我们使用D-半乳糖胺（GalN）研究了TRQ对大鼠原代培养肝细胞酶泄漏的影响，D-半乳糖胺可导致肝损伤但不发生脂质过氧化。添加GalN后18小时，谷丙转氨酶（GPT）和谷草转氨酶（GOT）的泄漏显著增加，在42 - 50小时达到饱和。在42小时时，TRQ可剂量依赖性地抑制这种酶泄漏，但维生素E则无此作用。这些结果表明，TRQ对肝细胞酶泄漏具有抑制作用，且与其对脂质过氧化的抑制作用无关。
