Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1 Street, 00-645, Warsaw, Poland.
Sci Rep. 2022 Jul 21;12(1):12455. doi: 10.1038/s41598-022-16720-3.
Inhalation is a non-invasive method of local drug delivery to the respiratory system. This study analyzed the potential use of aqueous dispersion of oxygen nanobubbles (ADON) as a drug carrier with the additional function of oxygen supplementation to diseased lungs. The suitability of the membrane-based method of ADON preparation and, next, the stability of ADON properties during storage and after aerosolization in nebulizers of various designs (jet, ultrasonic, and two vibrating mesh devices) was investigated. The increased oxygen content in the aerosol generated in two mesh nebulizers suggests that the proposed concept may be helpful in the oxygen supplementation during drug delivery by aerosol inhalation without using an additional oxygen source. This application can increase the overall effectiveness of lung disease treatment and pulmonary rehabilitation.
吸入是将药物递送到呼吸系统的一种非侵入性局部给药方法。本研究分析了将纳米氧气气泡水基分散体（ADON）作为药物载体的潜在用途，该载体具有向患病肺部补充氧气的附加功能。研究了基于膜的 ADON 制备方法的适用性，以及 ADON 在储存期间和在各种设计的雾化器（射流、超声和两种振动网装置）中雾化后的稳定性。在两个网孔雾化器中产生的气溶胶中的氧气含量增加表明，在不使用额外氧气源的情况下，通过气溶胶吸入进行药物输送期间补充氧气，这一概念可能具有帮助。这种应用可以提高肺部疾病治疗和肺康复的整体效果。
