Isaac Maxwell, Patel Paragkumar, Rojas-Moreno Christian, Nguyen Thai, Ahmed Ramia
University of Missouri, 1 Hospital Drive, Columbia, MO 65212, the United States of America.
IDCases. 2022 Jul 14;29:e01571. doi: 10.1016/j.idcr.2022.e01571. eCollection 2022.
Clinically significant cryptococcal disease is typically seen in patients with human immunodeficiency virus (HIV). However, Cryptococcosis has also been observed among non-HIV immunocompromised hosts. Cryptococcosis and tuberculosis (TB) infections both occur due to impaired cell mediated immunity but co-infection is rare among immunocompromised patients. Co-infection of these pathogens is even less reported in immunocompetent hosts. We present a case of Cryptococcal left native knee septic arthritis with tibial osteomyelitis in an HIV negative patient with recently active tuberculosis.
具有临床意义的隐球菌病通常见于人类免疫缺陷病毒（HIV）感染者。然而，在非HIV免疫功能低下的宿主中也观察到了隐球菌病。隐球菌病和结核病（TB）感染均因细胞介导的免疫功能受损而发生，但在免疫功能低下的患者中，这两种感染同时存在的情况很少见。在免疫功能正常的宿主中，这两种病原体同时感染的报道更是少见。我们报告了一例HIV阴性、近期患有活动性结核病的患者，其左膝原发性隐球菌性脓毒性关节炎合并胫骨骨髓炎。
