Burton Leticia, Weerasinghe Daminda P, Joffe David, Saunders Jennifer, Falk Gregory L, Van der Wall Hans
CNI Molecular Imaging and University of Notre Dame, Sydney.
Department of Respiratory Medicine, Royal North Shore Hospital, Sydney.
Multidiscip Respir Med. 2022 Jul 6;17:832. doi: 10.4081/mrm.2022.832. eCollection 2022 Jan 12.
Pertussis is an infectious disease of the respiratory tract with a changing epidemiology. An increasing incidence has been found in the adult population with recurrent infections possibly related to changes in the current vaccine. Is there an association between pertussis infection, refractory cough and atypical gastro-oesophageal reflux (GORD)? Does this magnify and compound respiratory complications?
Observational study which compares post-pertussis (n=103) with non-pertussis patients (n=105) with established GORD. Patients were assessed for laryngopharyngeal reflux and aspiration of refluxate by a novel scintigraphic study.
Both groups showed severe GORD in association with high rates of laryngopharyngeal reflux (LPR) and pulmonary aspiration and lung disease. High rates of hiatus hernia and clinical diagnosis of "atypical" asthma showed correlations with pulmonary aspiration.
A high level of new onset LPR and lung aspiration has been shown in patients with chronic cough after recent pertussis infection by a novel scintigraphic technique with fused hybrid x-ray computed tomography (SPECT/CT).
百日咳是一种呼吸道传染病，其流行病学情况不断变化。在成人人群中发病率不断上升，反复感染可能与当前疫苗的变化有关。百日咳感染、难治性咳嗽和非典型胃食管反流（GORD）之间是否存在关联？这是否会加剧和加重呼吸道并发症？
一项观察性研究，比较确诊患有GORD的百日咳后患者（n = 103）和非百日咳患者（n = 105）。通过一项新型闪烁扫描研究评估患者的喉咽反流和反流物误吸情况。
两组均显示出严重的GORD，伴有高比例的喉咽反流（LPR）、肺误吸和肺部疾病。高比例的食管裂孔疝和“非典型”哮喘的临床诊断与肺误吸相关。
通过新型融合杂交X射线计算机断层扫描闪烁扫描技术（SPECT/CT）显示，近期百日咳感染后的慢性咳嗽患者出现了高水平的新发LPR和肺误吸。
