儿童胃食管反流病与反复呼吸道感染之间是否存在潜在联系？
Is There a Potential Link between Gastroesophageal Reflux Disease and Recurrent Respiratory Tract Infections in Children?
作者信息
Lupu Vasile Valeriu, Stefanescu Gabriela, Buga Ana Maria Laura, Forna Lorenza, Tarca Elena, Starcea Iuliana Magdalena, Mihai Cristina Maria, Florescu Laura, Cernomaz Andrei Tudor, Mocanu Adriana, Tarca Viorel, Thet Aye Aung, Lupu Ancuta
机构信息
Pediatrics, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
出版信息
Diagnostics (Basel). 2023 Jul 7;13(13):2310. doi: 10.3390/diagnostics13132310.
BACKGROUND
The implications of gastroesophageal reflux disease in respiratory tract infections have been investigated over time. The aim of our study was to evaluate the relationship between these two pathologic entities and the outcome after proper antireflux treatment.
METHODS
A group of 53 children with recurrent respiratory tract infections admitted in the gastroenterology clinic of a children's hospital in North-East Romania was investigated for gastroesophageal reflux disease through 24 h pH-metry. Those with a Boix-Ochoa score higher than 11.99 received proton pump inhibitor treatment and were reevaluated after 2 months.
RESULTS
A total of 41 children were found with a positive Boix-Ochoa score. After 2 months of antireflux therapy, eight patients still had a positive Boix-Ochoa score.
CONCLUSIONS
Recurrent respiratory tract infections with symptoms resistant to treatment should be considered a reason to investigate for gastroesophageal reflux, because the symptoms may be due to micro- or macro-aspiration of the gastric refluxate or to an esophageal-bronchial reflex mediated through the vagal nerve.
背景
随着时间的推移，胃食管反流病在呼吸道感染中的影响已得到研究。我们研究的目的是评估这两种病理实体之间的关系以及适当的抗反流治疗后的结果。
方法
对罗马尼亚东北部一家儿童医院胃肠病科收治的53例反复呼吸道感染儿童进行了24小时pH值测定，以调查胃食管反流病。Boix-Ochoa评分高于11.99的患儿接受质子泵抑制剂治疗，并在2个月后重新评估。
结果
共发现41例患儿Boix-Ochoa评分呈阳性。抗反流治疗2个月后，8例患儿Boix-Ochoa评分仍为阳性。
结论
对治疗有抵抗症状的反复呼吸道感染应被视为调查胃食管反流的一个原因，因为症状可能是由于胃反流物的微量或大量吸入，或通过迷走神经介导的食管-支气管反射所致。
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