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免疫功能正常儿童的慢性空洞型肺曲霉病

Chronic cavitary pulmonary aspergillosis in an immunocompetent child.

作者信息

Davies Adeyinka A, Adegbite Ireti A, Akintan Patricia E, Ibrahim Usman O, Adekoya Abiola O, Oladele Rita O

机构信息

Department of Medical Microbiology & Parasitology, College of Medicine, University of Lagos, Lagos, Nigeria.

Department of Medical Microbiology & Parasitology, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria.

出版信息

Med Mycol Case Rep. 2022 Jul 14;37:33-36. doi: 10.1016/j.mmcr.2022.07.001. eCollection 2022 Sep.

DOI:10.1016/j.mmcr.2022.07.001
PMID:35865451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9294259/
Abstract

Chronic pulmonary aspergillosis (CPA) is a progressive and destructive disease of the lung parenchyma. We report a 9-year-old boy diagnosed with CPA with a positive Aspergillus IgG and chest imaging of cavitary lung lesions. He was treated with oral Itraconazole with significant improvement. This shows that an index of suspicion should be heightened in the paediatric population with cavitary lung lesions because not all cavitary lung lesions are caused by tuberculosis.

摘要

慢性肺曲霉病（CPA）是一种累及肺实质的进行性破坏性疾病。我们报告了一名9岁男孩，诊断为CPA，曲霉IgG阳性，胸部影像学显示有空洞性肺部病变。他接受了口服伊曲康唑治疗，病情有显著改善。这表明，对于有空洞性肺部病变的儿科患者，应提高警惕，因为并非所有空洞性肺部病变都是由结核病引起的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/9294259/ec5d3a8c8147/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/9294259/bfd470bf461f/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/9294259/714be3ff7f81/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/9294259/1a3fd3f30fc5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/9294259/ec5d3a8c8147/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/9294259/bfd470bf461f/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/9294259/714be3ff7f81/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/9294259/1a3fd3f30fc5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/9294259/ec5d3a8c8147/gr3.jpg

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本文引用的文献

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J Fungi (Basel). 2022 Apr 28;8(5):460. doi: 10.3390/jof8050460.
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Chronic cavitary pulmonary aspergillosis in an infant.婴儿慢性空洞性肺曲霉病
Lancet Infect Dis. 2021 Dec;21(12):1757. doi: 10.1016/S1473-3099(21)00351-0.
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Mapping of Chronic Pulmonary Aspergillosis in Africa.非洲慢性肺曲霉病的图谱绘制
J Fungi (Basel). 2021 Sep 23;7(10):790. doi: 10.3390/jof7100790.
4
Diagnosing pulmonary aspergillosis is much easier than it used to be: a new diagnostic landscape.诊断肺曲霉病比以往容易得多：新的诊断领域。
Int J Tuberc Lung Dis. 2021 Jul 1;25(7):525-536. doi: 10.5588/ijtld.21.0053.
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Manifestations of pulmonary aspergillosis in pediatrics.儿童肺曲霉病的表现。
Curr Opin Pediatr. 2020 Jun;32(3):389-394. doi: 10.1097/MOP.0000000000000898.
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Primary immunodeficiency.原发性免疫缺陷
Allergy Asthma Clin Immunol. 2018 Sep 12;14(Suppl 2):61. doi: 10.1186/s13223-018-0290-5. eCollection 2018.
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Treatment of Chronic Pulmonary Aspergillosis: Current Standards and Future Perspectives.慢性肺曲霉病的治疗：当前标准和未来展望。
Respiration. 2018;96(2):159-170. doi: 10.1159/000489474. Epub 2018 Jul 6.
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Chronic pulmonary aspergillosis as a cause of smear-negative TB and/or TB treatment failure in Nigerians.慢性肺曲霉病是导致尼日利亚人群中痰涂片阴性结核病和/或结核病治疗失败的原因。
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