Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Front Immunol. 2022 Jul 5;13:887326. doi: 10.3389/fimmu.2022.887326. eCollection 2022.
Currently, there is little literature about the association between physical activity (PA) and the risk of ankylosing spondylitis (AS). The present study aimed to understand the causal relationships between PA and AS.
We performed two-sample Mendelian randomization (MR) using publicly released genome-wide association studies summary statistics to estimate the causal associations of PA with AS risk. The inverse variance weighted (IVW) method was utilized as primary MR analysis. Furthermore, sensitivity, pleiotropy, and heterogeneity analyses were then conducted to assess the robustness of the findings of the present study.
Results of the IVW analysis suggested a protective relationship between accelerometer-based PA and AS (average acceleration, odds ratio [OR] = 0.9995, 95% CI, 0.9988-0.9999, P = 0.014). On the contrary, there was no causal relationship between accelerometer-based PA (acceleration fraction >425 mg; OR = 0.9981, 95% CI = 0.9936-1.0026, P = 0.402) and AS. Furthermore, there was no significant relationship between self-reported vigorous PA and AS (OR = 1.0005, 95% CI = 0.9875-1.0136, P = 0.943), or even between self-reported moderate-to-vigorous PA and AS (OR = 1.0000, 95% CI, 0.9947-1.0052; P = 0.990).
The use of genetic approach in the present study revealed that total physical activity (TPA) has a protective relationship with AS risk. Furthermore, it was evident that vigorous PA or moderate-to-vigorous physical levels are not causally associated with AS. Therefore, the present study evidently supports the hypothesis that enhancing TPA rather than PA intensity is an effective prevention strategy for AS.
目前，关于体力活动（PA）与强直性脊柱炎（AS）风险之间的关联的文献很少。本研究旨在了解 PA 与 AS 之间的因果关系。
我们使用公开发布的全基因组关联研究汇总统计数据进行了两样本孟德尔随机化（MR），以估计 PA 与 AS 风险之间的因果关系。采用逆方差加权（IVW）法作为主要 MR 分析。此外，还进行了敏感性、多效性和异质性分析，以评估本研究结果的稳健性。
IVW 分析结果表明，基于加速度计的 PA 与 AS 呈保护关系（平均加速度，比值比[OR] = 0.9995，95%置信区间，0.9988-0.9999，P = 0.014）。相反，基于加速度计的 PA（加速度分数>425 mg；OR = 0.9981，95%置信区间= 0.9936-1.0026，P = 0.402）与 AS 之间没有因果关系。此外，自我报告的剧烈 PA 与 AS 之间没有显著关系（OR = 1.0005，95%置信区间= 0.9875-1.0136，P = 0.943），甚至自我报告的中等到剧烈 PA 与 AS 之间也没有关系（OR = 1.0000，95%置信区间，0.9947-1.0052；P = 0.990）。
本研究采用遗传方法表明，总体力活动（TPA）与 AS 风险呈保护关系。此外，剧烈 PA 或中等到剧烈 PA 水平与 AS 没有因果关系。因此，本研究显然支持这样一种假设，即增加 TPA 而不是 PA 强度是预防 AS 的有效策略。
