Yan Zian, Chen Jingjing, Guo Lijun, Zhang Hongwei, Ding Yanqiu, Ren Gaocan, Mao Yiyi, Bai Ruina, Ma Xiaochang
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Front Psychiatry. 2024 Jun 6;15:1372842. doi: 10.3389/fpsyt.2024.1372842. eCollection 2024.
Although extensive research has explored the link between mental disorders and asthma, the characteristics and patterns of this association are still unclear. Our study aims to examine the genetic causal links between common mental disorders (specifically, anxiety and depression) and asthma.
We conducted genetic analyses including linkage disequilibrium score regression (LDSC) and bidirectional two-sample Mendelian randomization (MR) analyses, and utilized summary statistics from recent large-scale Genome-Wide Association Studies (GWASs) in European populations, covering sensation of anxiety or depression, anxiety sensation, depression sensation, anxiety disorders, major depression disorder (MDD), and asthma.
LDSC revealed significant genetic correlations among sensation of anxiety or depression, MDD and asthma ( < 0.017), highlighting potential genetic correlation between anxiety disorders and asthma ( < 0.05 yet > 0.017). In bidirectional two-sample MR, inverse-variance weighted (IVW) analyses suggested that genetic liability to asthma was significantly associated with an increased risk of sensation of anxiety or depression (OR = 4.760, 95%CI: 1.645-13.777), and MDD (OR = 1.658, 95%CI: 1.477-1.860). Conversely, IVW analyses indicated that genetic liability to anxiety disorders was not associated with an increased risk of asthma ( > 0.01), nor was genetic liability to asthma associated with an increased risk of anxiety disorders ( > 0.01). Furthermore, no significant genetic causal relationships were observed for other studied traits. Multivariate MR, after adjusting for body mass index and alcohol consumption, further corroborated the independent causal effect of genetic predisposition to MDD on the risk of asthma (OR = 1.460, 95% CI: 1.285-1.660).
Our study establishes MDD as a predisposing factor for asthma. Meanwhile, anxiety disorders are not causal risk factors for asthma, nor is the reverse true. It is recommended to closely monitor asthma symptoms in patients with MDD.
尽管大量研究探讨了精神障碍与哮喘之间的联系，但这种关联的特征和模式仍不明确。我们的研究旨在检验常见精神障碍（具体为焦虑和抑郁）与哮喘之间的遗传因果关系。
我们进行了遗传分析，包括连锁不平衡评分回归（LDSC）和双向双样本孟德尔随机化（MR）分析，并利用了欧洲人群近期大规模全基因组关联研究（GWAS）的汇总统计数据，涵盖焦虑或抑郁感觉、焦虑感觉、抑郁感觉、焦虑症、重度抑郁症（MDD）和哮喘。
LDSC显示焦虑或抑郁感觉、MDD和哮喘之间存在显著的遗传相关性（<0.017），突出了焦虑症与哮喘之间潜在的遗传相关性（<0.05但>0.017）。在双向双样本MR中，逆方差加权（IVW）分析表明，哮喘的遗传易感性与焦虑或抑郁感觉风险增加显著相关（OR = 4.760，95%CI：1.645 - 13.777），以及与MDD相关（OR = 1.658，95%CI：1.477 - 1.860）。相反，IVW分析表明，焦虑症的遗传易感性与哮喘风险增加无关（>0.01），哮喘的遗传易感性与焦虑症风险增加也无关（>0.01）。此外，对于其他研究性状未观察到显著的遗传因果关系。在调整体重指数和饮酒量后进行的多变量MR进一步证实了MDD的遗传易感性对哮喘风险的独立因果效应（OR = 1.460，95%CI：1.285 - 1.660）。
我们的研究确定MDD是哮喘的一个易感因素。同时，焦虑症不是哮喘的因果风险因素，反之亦然。建议密切监测MDD患者的哮喘症状。
