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侵袭性乳腺三阴性癌肉瘤的临床表现与治疗

Presentation and treatment of aggressive, Triple-Negative carcinosarcoma of the breast.

作者信息

Vizgan Niels, Jokar Tahereh Orouji, Enayati Ladan, Salyana Muhammad, Gotlieb Vladimir K

机构信息

Department of Chemistry Wesleyan University Middletown Connecticut USA.

St. Mary's General Hospital Passaic New Jersey USA.

出版信息

Clin Case Rep. 2022 Jul 18;10(7):e6020. doi: 10.1002/ccr3.6020. eCollection 2022 Jul.

DOI:10.1002/ccr3.6020
PMID:35865780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9291258/
Abstract

An extremely rare form of breast cancer, breast carcinosarcoma accounts for less than a percent of all breast malignancies and is highly aggressive. Composed of both cancerous epithelial and mesenchymal cell types, breast carcinosarcoma is associated with a poor prognosis compared to more common breast cancers, and typically lack the receptors typical of other breast carcinomas, which minimize potential targets for treatment. In this case report, we discuss a 56-year-old patient affected by carcinosarcoma of the breast at a T2N1 stage, and the decision-making process that factored into her treatment plan.

摘要

乳腺肉瘤样癌是一种极其罕见的乳腺癌形式,占所有乳腺恶性肿瘤的比例不到1%,且具有高度侵袭性。乳腺肉瘤样癌由癌性上皮细胞和间充质细胞类型组成,与更常见的乳腺癌相比,其预后较差,并且通常缺乏其他乳腺癌典型的受体,这使得潜在的治疗靶点减少。在本病例报告中,我们讨论了一名56岁处于T2N1期的乳腺肉瘤样癌患者,以及其治疗方案制定过程中的决策过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/5ad6256ed9b9/CCR3-10-e6020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/0e296f864c66/CCR3-10-e6020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/f201e6259762/CCR3-10-e6020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/b26f15029df2/CCR3-10-e6020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/65e9303c00d6/CCR3-10-e6020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/5ad6256ed9b9/CCR3-10-e6020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/0e296f864c66/CCR3-10-e6020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/f201e6259762/CCR3-10-e6020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/b26f15029df2/CCR3-10-e6020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/65e9303c00d6/CCR3-10-e6020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9770/9291258/5ad6256ed9b9/CCR3-10-e6020-g005.jpg

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本文引用的文献

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Single Hormone Receptor-Positive Metaplastic Breast Cancer: Similar Outcome as Triple-Negative Subtype.单一激素受体阳性化生性乳腺癌:与三阴性亚型具有相似的结局。
Front Endocrinol (Lausanne). 2021 Apr 23;12:628939. doi: 10.3389/fendo.2021.628939. eCollection 2021.
2
Metaplastic breast cancer: Treatment and prognosis by molecular subtype.化生性乳腺癌:按分子亚型分类的治疗与预后
Transl Oncol. 2021 May;14(5):101054. doi: 10.1016/j.tranon.2021.101054. Epub 2021 Mar 4.
3
An Update on the Molecular Pathology of Metaplastic Breast Cancer.
化生性乳腺癌分子病理学的最新进展
Breast Cancer (Dove Med Press). 2021 Feb 26;13:161-170. doi: 10.2147/BCTT.S296784. eCollection 2021.
4
TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer.TRPS1:乳腺癌的高度敏感和特异性标志物,特别是三阴性乳腺癌。
Mod Pathol. 2021 Apr;34(4):710-719. doi: 10.1038/s41379-020-00692-8. Epub 2020 Oct 3.
5
Metaplastic carcinoma of breast: a report of two cases.乳腺化生性癌:2例报告。
Oxf Med Case Reports. 2020 Sep 22;2020(9):omaa070. doi: 10.1093/omcr/omaa070. eCollection 2020 Sep.
6
Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors.癌肉瘤型乳腺癌病理亚型的定量蛋白质组学全景及其与三阴性肿瘤的关系。
Nat Commun. 2020 Apr 7;11(1):1723. doi: 10.1038/s41467-020-15283-z.
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