McCart Reed Amy E, Kalaw Emarene M, Lakhani Sunil R
UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.
Pathology Queensland, Brisbane, Queensland, Australia.
Breast Cancer (Dove Med Press). 2021 Feb 26;13:161-170. doi: 10.2147/BCTT.S296784. eCollection 2021.
Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of metaplasia that can present as spindle, squamous, chondroid or even osseous differentiation. MpBC are typically triple-negative, and are therefore not targetable with hormone therapy or anti-HER2 therapies, leaving only chemotherapeutics for management. MpBC are known for their aggressive course and poor response to chemotherapy. We review herein the pathology and molecular landscape of MpBC and discuss opportunities for targetted therapies as well as immunotherapies.
化生性乳腺癌（MpBC）是一种引人关注的乳腺癌形态学亚型，其特征为肿瘤内异质性。根据定义，这些肿瘤表现出化生区域，可呈现为梭形、鳞状、软骨样甚至骨样分化。MpBC通常为三阴性，因此不能用激素疗法或抗HER2疗法进行靶向治疗，治疗手段仅剩下化疗。MpBC以其侵袭性病程和对化疗反应不佳而闻名。我们在此回顾MpBC的病理学和分子格局，并讨论靶向治疗以及免疫治疗的机会。
