International Medical University, Hospital Tuanku Ja´afar, Seremban, Malaysia.
Pan Afr Med J. 2022 Apr 20;41:318. doi: 10.11604/pamj.2022.41.318.30147. eCollection 2022.
COVID-19 which first raised its deadly head in December 2019, has now engulfed the entire planet with its fire and fury. Mankind has been literally held to ransom by this micro-beast which has caused so much pain, sorrow and suffering, leaving behind scores of people dead and millions sick and gasping for air (quite literally!) The whole world is in disarray since the past 16 months, and now a new deadly superadded fungal infection has appeared in COVID-19 patients, in parts of the Indian subcontinent; namely mucormycosis, the deadly "black fungus." This persistent, unrelenting fungal infection which is relatively resistant to conventional anti-fungal treatment, sometimes requires radical, extensive surgical intervention in order to stem the spread of infection to vital organs such as the heart, brain, orbital spaces and spleen. mucormycosis has been increasingly seen to occur in COVID-19 patients who are immunocompromised and have uncontrolled diabetes mellitus as a comorbidity. Commonly seen forms of mucormycosis in COVID-19 patients include, Rhinocerebral mucormycosis and Pulmonary mucormycosis, with some patients also developing the cutaneous form, while some manifesting the more serious disseminated form of mucormycosis.
COVID-19 于 2019 年 12 月首次出现,现已肆虐全球。这种微小的生物给人类带来了巨大的痛苦、悲伤和苦难,导致数百人死亡,数百万人患病并呼吸困难(毫不夸张!)。自过去 16 个月以来,全世界都陷入混乱,现在 COVID-19 患者中出现了一种新的致命真菌感染,在印度次大陆的部分地区;即毛霉菌病,致命的“黑真菌”。这种持续不断、不屈不挠的真菌感染对常规抗真菌治疗具有一定的耐药性,有时需要进行激进的广泛手术干预,以阻止感染扩散到心脏、大脑、眼眶和脾脏等重要器官。毛霉菌病在免疫功能低下和患有未控制的糖尿病等合并症的 COVID-19 患者中越来越常见。COVID-19 患者中常见的毛霉菌病形式包括鼻脑毛霉菌病和肺毛霉菌病,一些患者还出现皮肤形式,而一些则表现出更严重的播散性毛霉菌病。