Trahan C J, LeDuc J W, Staley E C, Binn L N, Marchwicki R H, Lemon S M, Keenan C M, Bancroft W H
Lab Anim Sci. 1987 Feb;37(1):45-50.
Several species of nonhuman primates have served as animal models for hepatitis A virus (HAV) infection and disease. This study was to determine the suitability of Aotus trivirgatus as an orally induced model for HAV infection and to reconfirm the owl monkey's susceptibility to the intravenous route of inoculation. Animals were inoculated, either orally or intravenously, with varying concentrations of PA-33 strain of HAV. Serum enzymes ALT, AST and GGTP levels were monitored and liver biopsies performed when values exceeded three standard deviations above individualized mean baseline values. All animals had postinoculation elevations of serum ALT and AST values, shed virus in their feces, and were seropositive to HAV by 60 days after inoculation. Eight of the ten postinoculation biopsy specimens had histologic lesions compatible with acute viral hepatitis. We conclude that the owl monkey is a useful and valuable model for the study of HAV disease.
几种非人灵长类动物已被用作甲型肝炎病毒（HAV）感染和疾病的动物模型。本研究旨在确定三带犰狳作为口服诱导HAV感染模型的适用性，并再次确认夜猴对静脉接种途径的易感性。给动物口服或静脉接种不同浓度的HAV PA-33株。监测血清酶ALT、AST和GGTP水平，当值超过个体平均基线值以上三个标准差时进行肝活检。所有动物接种后血清ALT和AST值均升高，粪便中排出病毒，接种后60天对HAV血清学呈阳性。十个接种后活检标本中有八个具有与急性病毒性肝炎相符的组织学病变。我们得出结论，夜猴是研究HAV疾病的有用且有价值的模型。
