Fraser C E
Lab Anim Sci. 1976 Dec;26(6 Pt 2):1138-41.
The owl monkey, Aotus trivirgatus, in contrast to other species of nonhuman primates, was shown to be susceptable to infection with strains of Chlamydia trachomatis. It responded to experimental infection with a severe, acute, inflammatory reaction of short duration. Monkeys which recovered from infection were resistant to reinfection for more than 6 months and resistance was not strain specific. Eye secretion antibody titers correlated well with resistance to subsequent challenge. These studies taken together, established the owl monkey as a good animal model in which to study the pathogenesis and the immune responses to infection with C trachomatis.
与其他非人灵长类动物不同，夜猴（Aotus trivirgatus）被证明易受沙眼衣原体菌株的感染。它对实验性感染的反应是严重、急性的短期炎症反应。从感染中恢复的猴子对再次感染具有超过6个月的抵抗力，且这种抵抗力并非菌株特异性的。眼部分泌物抗体滴度与对后续攻击的抵抗力密切相关。综合这些研究，确立了夜猴作为研究沙眼衣原体感染的发病机制和免疫反应的良好动物模型。
