Felim Jerrell, Chen Chun-Kai, Tsou David, Kuo Hsiang-Ping, Kong Zwe-Ling
Laboratory of Cellular Immunology, Department of Food Science, National Taiwan Ocean University, Keelung City, Taiwan.
Biotaiwan Foundation, New Taipei City, Taiwan.
Front Bioeng Biotechnol. 2022 Jul 5;10:917474. doi: 10.3389/fbioe.2022.917474. eCollection 2022.
Osteoarthritis (OA) is a common type of arthritis characterized by degeneration of the articular cartilage and joint dysfunction. Various pharmacological and non-pharmacological techniques have been used to manage these diseases. Due to the diverse therapeutic properties of marine collagen, it has received considerable attention in its pharmacological application. Thus, the purpose of this study was to compare the efficacy of jellyfish collagen, collagen peptide, other sources of marine collagen, and glycine in treating OA. In the OA rat model, an anterior cruciate ligament transection combined with medial meniscectomy surgery (ACLT + MMx) was used to induce osteoarthritis in rats. Two weeks before surgery, male Sprague-Dawley rats were fed a chow-fat diet. After 6 weeks of treatment with collagen, collagen peptide, and glycine, the results show that they could inhibit the production of proinflammatory cytokines and their derivatives, such as COX-2, MMP-13, and CTX-II levels; therefore, it can attenuate cartilage degradation. Moreover, collagen peptides can promote the synthesis of collagen type II in cartilage. These results demonstrate that collagen and glycine have been shown to have protective properties against OA cartilage degradation. In contrast, collagen peptides have been shown to show cartilage regeneration but less protective properties. Jellyfish collagen peptide at a dose of 5 mg/kg b. w. has the most significant potential for treating OA because it protects and regenerates cartilage in the knee.
骨关节炎（OA）是一种常见的关节炎类型，其特征为关节软骨退变和关节功能障碍。人们已采用各种药理学和非药理学技术来治疗这些疾病。由于海洋胶原蛋白具有多种治疗特性，其在药理学应用中受到了广泛关注。因此，本研究的目的是比较海蜇胶原蛋白、胶原蛋白肽、其他海洋胶原蛋白来源以及甘氨酸在治疗骨关节炎方面的疗效。在骨关节炎大鼠模型中，采用前交叉韧带横断联合内侧半月板切除术（ACLT + MMx）诱导大鼠患骨关节炎。手术前两周，给雄性斯普拉格-道利大鼠喂食高脂饲料。在用胶原蛋白、胶原蛋白肽和甘氨酸治疗6周后，结果表明它们能够抑制促炎细胞因子及其衍生物的产生，如COX-2、MMP-13和CTX-II水平；因此，它可以减轻软骨降解。此外，胶原蛋白肽可以促进软骨中II型胶原蛋白的合成。这些结果表明，胶原蛋白和甘氨酸已被证明对骨关节炎软骨降解具有保护作用。相比之下，胶原蛋白肽已被证明具有软骨再生作用，但保护作用较弱。剂量为5 mg/kg体重的海蜇胶原蛋白肽在治疗骨关节炎方面具有最显著的潜力，因为它可以保护和再生膝关节软骨。
