Mason Matt, Gregory Eric, Foster Keith, Klatt Megan, Zoubek Sara, Eid Albert J
Department of Pharmacy, The University of Kansas Health System, Kansas City, Kansas, USA.
Department of Medicine, Division of Infectious Diseases, Kansas City, Kansas, USA.
Open Forum Infect Dis. 2022 Jun 15;9(7):ofac287. doi: 10.1093/ofid/ofac287. eCollection 2022 Jul.
, a member of the complex, can cause infections in individuals after open heart surgery due to contaminated heater-cooler units. The diagnosis can be challenging, as the incubation period can be quite variable, and symptoms are nonspecific. In addition to aggressive surgical management, combination pharmacologic therapy is the cornerstone of therapy, which should consist of a macrolide, a rifamycin, ethambutol, and amikacin. Multiple second-line agents may be utilized in the setting of intolerances or toxicities. susceptibility of these agents is similar to activity against other species in the complex. Drug-drug interactions are frequently encountered, as many individuals have chronic medical comorbidities and are prescribed medications that interact with the first-line agents used to treat . Recognition of these drug-drug interactions and appropriate management are essential for optimizing treatment outcomes.
作为复合体的一员，由于加热器 - 冷却器单元被污染，可在心脏直视手术后导致个体感染。诊断可能具有挑战性，因为潜伏期变化很大，且症状不具特异性。除积极的手术治疗外，联合药物治疗是治疗的基石，应包括大环内酯类、利福霉素、乙胺丁醇和阿米卡星。在不耐受或出现毒性的情况下，可使用多种二线药物。这些药物对该复合体中其他菌种的敏感性与活性相似。由于许多个体有慢性内科合并症且正在服用与用于治疗该疾病的一线药物相互作用的药物，因此经常会遇到药物相互作用。认识到这些药物相互作用并进行适当管理对于优化治疗结果至关重要。
