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血液恶性肿瘤患者转至姑息治疗门诊的时机。

Timing of referral to outpatient palliative care for patients with haematologic malignancies.

机构信息

Department of Palliative Care, Rochester General Hospital, Rochester, New York, USA.

Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, Texas, USA.

出版信息

Br J Haematol. 2022 Sep;198(6):974-982. doi: 10.1111/bjh.18365. Epub 2022 Jul 21.

DOI:10.1111/bjh.18365
PMID:35866185
Abstract

Outpatient palliative-care facilitates timely supportive-care access; however, there is a paucity of studies on the timing of referral in the outpatient setting for patients with haematologic malignancy. We examined the trend in timing of outpatient palliative-care referrals over a 10-year period in patients with haematologic malignancies at our comprehensive cancer centre. We included consecutive patients with a diagnosis of haematologic malignancy who were seen at our outpatient palliative-care clinic between 1 January 2010 and 31 December 2019. We collected data on patient characteristics, symptom burden and supportive-care interventions at outpatient palliative-care consultation. The primary outcome was time from outpatient palliative-care consultation to death or last follow-up. In all, 384 patients were referred by leukaemia (n = 143), lymphoma (n = 213), and stem cell transplant (n = 28) services. The median time from outpatient palliative-care referral to death was 3.4 years (IQR 2.4-5.3) with a significant increase in both the number of referrals per year (p = 0.047) and the timing of referral between 2010 and 2019 (p = 0.001). Patients with haematologic malignancies were referred in a timely fashion to our outpatient palliative-care clinic, with earlier and greater numbers of referrals over time.

摘要

门诊姑息治疗有助于及时获得支持性护理;然而,对于血液恶性肿瘤患者,门诊姑息治疗的转诊时机研究较少。我们检查了在我们的综合癌症中心,10 年间门诊姑息治疗门诊就诊的血液恶性肿瘤患者的转诊时机趋势。我们纳入了在 2010 年 1 月 1 日至 2019 年 12 月 31 日期间在我们的门诊姑息治疗诊所就诊的连续诊断为血液恶性肿瘤的患者。我们收集了患者特征、症状负担和门诊姑息治疗咨询时的支持性护理干预的数据。主要结果是从门诊姑息治疗咨询到死亡或最后一次随访的时间。共有 384 例患者分别由白血病(n=143)、淋巴瘤(n=213)和干细胞移植(n=28)服务转诊。从门诊姑息治疗转介到死亡的中位数时间为 3.4 年(IQR 2.4-5.3),每年的转介人数(p=0.047)和 2010 年至 2019 年之间的转介时间(p=0.001)均显著增加。血液恶性肿瘤患者及时转至我们的门诊姑息治疗诊所,随着时间的推移,转介的数量更早、更多。

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Early palliative/supportive care in acute myeloid leukaemia allows low aggression end-of-life interventions: observational outpatient study.急性髓系白血病的早期姑息/支持性治疗允许采用低强度的临终干预措施:门诊观察性研究。
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