• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

站在微生物的肩膀上：癌症生物学家如何扩大对难以杀死的持续存在细胞的认识。

Standing on the shoulders of microbes: How cancer biologists are expanding their view of hard-to-kill persister cells.

机构信息

Department of Human Molecular Genetics & Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

Mol Syst Biol. 2022 Jul;18(7):e11168. doi: 10.15252/msb.202211168.

DOI:10.15252/msb.202211168
PMID:35866381
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9305393/
Abstract

Similar to persister bacterial cells that survive antibiotic treatments, some cancer cells can evade drug treatments. This Commentary discusses the different classes of persister cells and their implications for developing more efficient cancer treatments.

摘要

类似于能在抗生素治疗中存活的持留菌细胞，一些癌细胞能逃避药物治疗。本文述评讨论了不同类型的持留细胞及其对开发更有效的癌症治疗方法的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f2/9305393/2c02aa00bd2a/MSB-18-e11168-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f2/9305393/2c02aa00bd2a/MSB-18-e11168-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f2/9305393/2c02aa00bd2a/MSB-18-e11168-g002.jpg

相似文献

1
Standing on the shoulders of microbes: How cancer biologists are expanding their view of hard-to-kill persister cells.站在微生物的肩膀上：癌症生物学家如何扩大对难以杀死的持续存在细胞的认识。
Mol Syst Biol. 2022 Jul;18(7):e11168. doi: 10.15252/msb.202211168.
2
Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment.持留型大肠杆菌细胞的细胞内pH值低于敏感型细胞，但在抗生素处理时能维持其pH值。
mBio. 2021 Aug 31;12(4):e0090921. doi: 10.1128/mBio.00909-21. Epub 2021 Jul 20.
3
Prophages and Growth Dynamics Confound Experimental Results with Antibiotic-Tolerant Persister Cells.噬菌体和生长动态使抗生素耐受持久细胞的实验结果复杂化。
mBio. 2017 Dec 12;8(6):e01964-17. doi: 10.1128/mBio.01964-17.
4
Identification of antibiotic induced persister cells in Streptococcus agalactiae.鉴定无乳链球菌中的抗生素诱导持留细胞。
PLoS One. 2024 Jun 26;19(6):e0303271. doi: 10.1371/journal.pone.0303271. eCollection 2024.
5
Ciprofloxacin-induced persister-cells in .环丙沙星诱导 中的持留细胞。
Microbiology (Reading). 2020 Sep;166(9):849-853. doi: 10.1099/mic.0.000953. Epub 2020 Jul 22.
6
A high-throughput assay identifies molecules with antimicrobial activity against persister cells.高通量测定法鉴定出具有抗休眠细胞抗菌活性的分子。
J Med Microbiol. 2024 Jul;73(7). doi: 10.1099/jmm.0.001856.
7
Caffeine-loaded gold nanoparticles: antibiofilm and anti-persister activities against pathogenic bacteria.负载咖啡因的金纳米颗粒：对病原菌的抗生物膜和抗持留菌活性
Appl Microbiol Biotechnol. 2021 May;105(9):3717-3731. doi: 10.1007/s00253-021-11300-3. Epub 2021 Apr 26.
8
Persisters Formation and Resuscitation.持久菌形成与复苏。
J Microbiol Biotechnol. 2024 Apr 28;34(4):854-862. doi: 10.4014/jmb.2312.12035. Epub 2024 Jan 29.
9
The fatty acid signaling molecule cis-2-decenoic acid increases metabolic activity and reverts persister cells to an antimicrobial-susceptible state.脂肪酸信号分子顺式-2-癸烯酸可提高代谢活性，并使持留菌细胞恢复到对抗菌药物敏感的状态。
Appl Environ Microbiol. 2014 Nov;80(22):6976-91. doi: 10.1128/AEM.01576-14. Epub 2014 Sep 5.
10
Lipidome of Acinetobacter baumannii antibiotic persister cells.鲍曼不动杆菌抗生素抗性休眠细胞的脂组学研究。
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Oct;1869(7):159539. doi: 10.1016/j.bbalip.2024.159539. Epub 2024 Jul 26.

引用本文的文献

1
The apicoplast is important for the viability and persistence of bradyzoites.类质体对于缓殖子的存活和持续存在很重要。
Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2309043120. doi: 10.1073/pnas.2309043120. Epub 2023 Aug 17.
2
Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids.探讨结直肠癌肝转移：在结直肠癌患者衍生类器官中寻找具有临床应用价值的化合物和机制见解。
J Exp Clin Cancer Res. 2023 Jul 17;42(1):170. doi: 10.1186/s13046-023-02754-6.
3
Breaking spore dormancy in budding yeast transforms the cytoplasm and the solubility of the proteome.

本文引用的文献

1
Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity.细胞毒性 T 细胞能够通过附加细胞毒性有效地消除癌细胞。
Nat Commun. 2021 Sep 1;12(1):5217. doi: 10.1038/s41467-021-25282-3.
2
Cycling cancer persister cells arise from lineages with distinct programs.循环肿瘤干细胞由具有不同特性的细胞谱系产生。
Nature. 2021 Aug;596(7873):576-582. doi: 10.1038/s41586-021-03796-6. Epub 2021 Aug 11.
3
Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer.癌症中靶向治疗耐受持久性细胞的新见解
芽殖酵母中孢子休眠的打破会改变细胞质和蛋白质组的可溶性。
PLoS Biol. 2023 Apr 20;21(4):e3002042. doi: 10.1371/journal.pbio.3002042. eCollection 2023 Apr.
Cancers (Basel). 2021 May 28;13(11):2666. doi: 10.3390/cancers13112666.
4
Persistent Cancer Cells: The Deadly Survivors.持久癌细胞：致命幸存者。
Cell. 2020 Nov 12;183(4):860-874. doi: 10.1016/j.cell.2020.10.027.
5
Understanding Lineage Plasticity as a Path to Targeted Therapy Failure in -Mutant Non-small Cell Lung Cancer.理解谱系可塑性作为KRAS突变型非小细胞肺癌靶向治疗失败的一条途径
Front Genet. 2020 Mar 27;11:281. doi: 10.3389/fgene.2020.00281. eCollection 2020.
6
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.耐药物持久性癌细胞易受谷胱甘肽过氧化物酶4（GPX4）抑制的影响。
Nature. 2017 Nov 9;551(7679):247-250. doi: 10.1038/nature24297. Epub 2017 Nov 1.
7
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.癌基因和抑癌基因对代谢开关的控制。
Science. 2010 Dec 3;330(6009):1340-4. doi: 10.1126/science.1193494.
8
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.肿瘤细胞亚群中染色质介导的可逆药物耐受状态。
Cell. 2010 Apr 2;141(1):69-80. doi: 10.1016/j.cell.2010.02.027.