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介孔硅材料作为癌症免疫治疗的一种新兴工具。

Mesoporous Silica Materials as an Emerging Tool for Cancer Immunotherapy.

机构信息

Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.

Universitat Politècnica de València, Joint Unit UPV-CIPF of Developmental Biology and Disease Models and Nanomedicine, Polytechnic University of Valencia (UPV)-Príncipe Felipe Research Center Foundation (CIPF), C/ Eduardo Primo Yúfera 3., Valencia, 46012, Spain.

出版信息

Adv Sci (Weinh). 2022 Sep;9(26):e2200756. doi: 10.1002/advs.202200756. Epub 2022 Jul 22.

DOI:10.1002/advs.202200756
PMID:35866466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9475525/
Abstract

Cancer immunotherapy has emerged in the past decade as a promising strategy for treating many forms of cancer by stimulating the patient's immune system. Although immunotherapy has achieved some promising results in clinics, more efforts are required to improve the limitations of current treatments related to lack of effective and targeted cancer antigens delivery to immune cells, dose-limiting toxicity, and immune-mediated adverse effects, among others. In recent years, the use of nanomaterials has proven promising to enhance cancer immunotherapy efficacy and reduce side effects. Among nanomaterials, attention has been recently paid to mesoporous silica nanoparticles (MSNs) as a potential multiplatform for enhancing cancer immunotherapy by considering their unique properties, such as high porosity, and good biocompatibility, facile surface modification, and self-adjuvanticity. This review explores the role of MSN and other nano/micro-materials as an emerging tool to enhance cancer immunotherapy, and it comprehensively summarizes the different immunotherapeutic strategies addressed to date by using MSN.

摘要

在过去的十年中，癌症免疫疗法作为一种有前途的策略出现，通过刺激患者的免疫系统来治疗多种形式的癌症。尽管免疫疗法在临床上已经取得了一些有希望的结果，但仍需要更多的努力来改善当前治疗方法的局限性，这些局限性与缺乏有效和靶向的癌症抗原递送至免疫细胞、剂量限制毒性和免疫介导的不良反应等有关。近年来，纳米材料的应用已被证明可以提高癌症免疫疗法的疗效并降低副作用。在纳米材料中，介孔硅纳米粒子（MSNs）由于其独特的性质，如高孔隙率、良好的生物相容性、易于表面修饰和自佐剂性等，最近引起了人们的关注，被认为是增强癌症免疫疗法的一种潜在多平台。本文探讨了 MSN 及其他纳米/微米材料作为增强癌症免疫疗法的新兴工具的作用，并全面总结了迄今为止使用 MSN 解决的不同免疫治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/5fa0e2f6abeb/ADVS-9-2200756-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/63228ea65151/ADVS-9-2200756-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/f09085604653/ADVS-9-2200756-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/a5c5b65aafeb/ADVS-9-2200756-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/4e4b707cc32f/ADVS-9-2200756-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/30fd9f285588/ADVS-9-2200756-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/05c6763822ad/ADVS-9-2200756-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/c686bea5f872/ADVS-9-2200756-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/bd0a80e6616c/ADVS-9-2200756-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/ea0e792847ed/ADVS-9-2200756-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/1dcfea518754/ADVS-9-2200756-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/16785ab20f88/ADVS-9-2200756-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/9bf57865c328/ADVS-9-2200756-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/5fa0e2f6abeb/ADVS-9-2200756-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/63228ea65151/ADVS-9-2200756-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/f09085604653/ADVS-9-2200756-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/a5c5b65aafeb/ADVS-9-2200756-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/4e4b707cc32f/ADVS-9-2200756-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/30fd9f285588/ADVS-9-2200756-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/05c6763822ad/ADVS-9-2200756-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/c686bea5f872/ADVS-9-2200756-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/bd0a80e6616c/ADVS-9-2200756-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/ea0e792847ed/ADVS-9-2200756-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/1dcfea518754/ADVS-9-2200756-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/16785ab20f88/ADVS-9-2200756-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/9bf57865c328/ADVS-9-2200756-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/9475525/5fa0e2f6abeb/ADVS-9-2200756-g006.jpg

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本文引用的文献

[1]
Nanoprogrammed Cross-Kingdom Communication Between Living Microorganisms.

Nano Lett. 2022-3-9

[2]
Mesoporous Silica Nanoparticles Doped with Gold Nanoparticles for Combined Cancer Immunotherapy and Photothermal Therapy.

ACS Appl Bio Mater. 2019-8-19

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Cancer immunotherapy: Challenges and limitations.

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Clinical translation of silica nanoparticles.

Nat Rev Mater. 2021

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Chem Sci. 2020-12-9

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Chem Soc Rev. 2021-8-21

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Engineered drug-loaded cells and cell derivatives as a delivery platform for cancer immunotherapy.

Biomater Sci. 2021-2-21

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Int J Nanomedicine. 2020-11-6

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Colloids Surf B Biointerfaces. 2021-1

[10]
Metal-Phenolic Network-Encapsulated Nanovaccine with pH and Reduction Dual Responsiveness for Enhanced Cancer Immunotherapy.

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