Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Solna, Sweden.
Behav Genet. 2022 Sep;52(4-5):306-314. doi: 10.1007/s10519-022-10109-8. Epub 2022 Jul 22.
The cell adhesion molecule 2 (CADM2) gene has appeared among the top associations in a wide range of genome-wide association studies (GWASs). This study aims to: (1) examine how widespread the role of CADM2 is in behavioural traits, and (2) investigate trait-specific effects on CADM2 expression levels across tissues. We conducted a phenome-wide association study in UK Biobank (N = 12,211-453,349) on 242 psycho-behavioral traits, both at the SNP and the gene-level. For comparison, we repeated the analyses for other large (and high LD) genes. We found significant associations between CADM2 and 50 traits (including cognitive, risk taking, and dietary traits), many more than for the comparison genes. We show that many trait associations are reduced when taking geographical stratification into account. S-Predixcan revealed that CADM2 expression in brain tissues was significantly associated with many traits; highly significant effects were also observed for lung, mammary, and adipose tissues. In conclusion, this study shows that the role of CADM2 extends to a wide range of psycho-behavioral traits, suggesting these traits may share a common biological denominator.
细胞黏附分子 2 (CADM2) 基因在广泛的全基因组关联研究 (GWAS) 中名列前茅。本研究旨在：(1) 研究 CADM2 在行为特征中的作用有多普遍，以及 (2) 研究 CADM2 在组织中的表达水平对特定性状的影响。我们在英国生物银行 (UK Biobank) 进行了一项表型全基因组关联研究 (N=12211-453349)，研究了 242 种心理行为特征，包括 SNP 和基因水平。作为比较，我们还对其他大型（和高 LD）基因进行了重复分析。我们发现 CADM2 与 50 个特征（包括认知、风险承担和饮食特征）之间存在显著关联，比比较基因多得多。我们表明，许多性状关联在考虑地理分层时会减少。S-Predixcan 表明，CADM2 在脑组织中的表达与许多性状显著相关；在肺、乳腺和脂肪组织中也观察到高度显著的影响。总之，这项研究表明 CADM2 的作用扩展到广泛的心理行为特征，表明这些特征可能具有共同的生物学基础。
