Boutwell Brian, Hinds David, Tielbeek Jorim, Ong Ken K, Day Felix R, Perry John R B
School of Social Work, College for Public Health and Social Justice, Saint Louis University, 3550 Lindell Blvd. St. Louis, MO 63103, USA.
Department of Epidemiology, College for Public Health and Social Justice, Salus Center 3545 Lafayette Avenue St. Louis, MO 63104, USA.
Heliyon. 2017 Jul 26;3(7):e00349. doi: 10.1016/j.heliyon.2017.e00349. eCollection 2017 Jul.
Progress identifying the genetic determinants of personality has historically been slow, with candidate gene studies and small-scale genome-wide association studies yielding few reproducible results. In the UK Biobank study, genetic variants in and were recently shown to influence risk taking behavior and irritability respectively, representing some of the first genomic loci to be associated with aspects of personality. We extend this observation by performing a personality "phenome-scan" across 16 traits in up to 140,487 participants from 23andMe for these two genes. Genome-wide heritability estimates for these traits ranged from 5-19%, with both and demonstrating significant effects on multiple personality types. These associations covered all aspects of the big five personality domains, including specific facet traits such as compliance, altruism, anxiety and activity/energy. This study both confirms and extends the original observations, highlighting the role of genetics in aspects of mental health and behavior.
从历史上看，确定人格遗传决定因素的进展一直缓慢，候选基因研究和小规模全基因组关联研究产生的可重复结果很少。在英国生物银行研究中，最近发现某基因和另一基因的遗传变异分别影响冒险行为和易怒性，这是首批与人格方面相关的一些基因组位点。我们通过对来自23andMe的多达140487名参与者中的这两个基因进行16种特质的人格“表型扫描”来扩展这一观察结果。这些特质的全基因组遗传率估计值在5%至19%之间，某基因和另一基因对多种人格类型均显示出显著影响。这些关联涵盖了大五人格领域的所有方面，包括顺从、利他主义、焦虑和活力等特定方面特质。这项研究既证实又扩展了最初的观察结果，突出了遗传学在心理健康和行为方面的作用。
