Microbiomics Unit, Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy; Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.
Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.
Mech Ageing Dev. 2022 Sep;206:111711. doi: 10.1016/j.mad.2022.111711. Epub 2022 Jul 20.
The gut microbiome is undoubtedly a key modulator of human health, which can promote or impair homeostasis throughout life. This is even more relevant in old age, when there is a gradual loss of function in multiple organ systems, related to growth, metabolism, and immunity. Several studies have described changes in the gut microbiome across age groups up to the extreme limits of lifespan, including maladaptations that occur in the context of age-related conditions, such as frailty, neurodegenerative diseases, and cardiometabolic diseases. The gut microbiome can also interact bi-directionally with anti-age-related disease therapies, being affected and in turn influencing their efficacy. In this framework, the development of integrated microbiome-based intervention strategies, aimed at favoring a eubiotic configuration and trajectory, could therefore represent an innovative approach for the promotion of healthy aging and the achievement of longevity.
肠道微生物组无疑是人类健康的关键调节剂，它可以促进或破坏整个生命周期的体内平衡。在老年时，这种情况更为相关，因为此时多个器官系统的功能会逐渐丧失，这与生长、代谢和免疫有关。多项研究描述了肠道微生物组在年龄组之间的变化，直到寿命的极限，包括与年龄相关的疾病（如衰弱、神经退行性疾病和心血管代谢疾病）相关的适应不良。肠道微生物组也可以与抗与年龄相关疾病的治疗方法双向相互作用，受到影响并反过来影响其疗效。在这种情况下，开发基于微生物组的综合干预策略，旨在促进有益的生态位和轨迹，因此可能代表了促进健康衰老和实现长寿的创新方法。
