Besora-Moreno Maria, Llauradó Elisabet, Valls Rosa M, Pedret Anna, Solà Rosa
Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Departament de Medicina i Cirurgia, Functional Nutrition, Oxidation, and Cardiovascular Diseases Group, 43201 Reus, Spain.
Institut Investigació Sanitària Pere i Virgili, 43204 Reus, Spain.
Nutr Rev. 2024 Oct 15. doi: 10.1093/nutrit/nuae145.
There is scarce evidence about which probiotic, prebiotic, or synbiotic supplementation is the most appropriate to improve sarcopenia parameters, and this presents a challenge.
The effects of consumption of probiotics, prebiotics, and synbiotics on sarcopenia, muscle strength, muscle mass, and physical performance and function were assessed in this study. In addition, another aim of the study was to determine the best probiotic, prebiotic, and/or synbiotic for the management of sarcopenia in older adults.
A systematic search was conducted in the MEDLINE/PubMed, Cochrane Library, SCOPUS databases, and other sources (eg, references obtained from articles identified in databases).
The search was limited from 2000 to 2023 and was based on sarcopenia parameters, and probiotics, prebiotics, or synbiotics supplementation. The quality of each included study also was assessed.
A meta-analysis was performed with the Review Manager program and publication bias and sensitivity analysis were performed.
Eight randomized controlled trials (RCTs) were included in the systematic review and 4 in the meta-analysis. Results showed that probiotics supplementation improved muscle strength and physical performance and function and suggested a beneficial effect on muscle mass. Prebiotics are suggested to be effective on muscle strength. The meta-analysis also determined that probiotic interventions were effective in increasing muscle strength by handgrip strength (mean difference [MD], 2.50 kg [95% CI, 1.33-3.66]; P < .0001) and physical performance and function by gait speed (MD, 0.10 m/s [95% CI, 1.33-3.66]; P < .0001) and physical performance and function by gait speed (MD, 0.10 m/s [95%CI, 0.03-0.16]; P = .003), but when sensitivity analysis was applied, the effectiveness was only maintained for gait speed.
Nutritional strategies based on probiotic supplementation seem to improve muscle strength and physical function. More robust research is needed with high-quality RCTs to confirm probiotics' effects. There is still limited evidence about prebiotic and synbiotic strategies, and more evidence is needed to elucidate their effects on sarcopenia parameters.
PROSPERO registration no. CRD42022360514.
关于哪种益生菌、益生元或合生元补充剂最适合改善肌肉减少症参数的证据很少，这是一个挑战。
本研究评估了食用益生菌、益生元和合生元对肌肉减少症、肌肉力量、肌肉质量以及身体性能和功能的影响。此外，该研究的另一个目的是确定用于管理老年人肌肉减少症的最佳益生菌、益生元和/或合生元。
在MEDLINE/PubMed、Cochrane图书馆、SCOPUS数据库以及其他来源（例如，从数据库中识别的文章中获得的参考文献）进行了系统检索。
检索限于2000年至2023年，并基于肌肉减少症参数以及益生菌、益生元或合生元补充剂。还评估了每项纳入研究的质量。
使用Review Manager程序进行荟萃分析，并进行发表偏倚和敏感性分析。
系统评价纳入了8项随机对照试验（RCT），荟萃分析纳入了4项。结果表明，补充益生菌可改善肌肉力量、身体性能和功能，并提示对肌肉质量有有益影响。益生元被认为对肌肉力量有效。荟萃分析还确定，益生菌干预可有效增加握力肌肉力量（平均差[MD]，2.50千克[95%置信区间，1.33 - 3.66]；P <.0001），并通过步速改善身体性能和功能（MD，0.10米/秒[95%置信区间，1.33 - 3.66]；P <.0001）以及通过步速改善身体性能和功能（MD，0.10米/秒[95%置信区间，0.03 - 0.16]；P =.003），但应用敏感性分析时，有效性仅在步速方面得以维持。
基于补充益生菌的营养策略似乎可改善肌肉力量和身体功能。需要进行更有力的高质量RCT研究以证实益生菌的效果。关于益生元和合生元策略的证据仍然有限，需要更多证据来阐明它们对肌肉减少症参数的影响。
PROSPERO注册号CRD42022360514。
