婴儿期无晶状体眼治疗研究中 10 年半时的有效晶状体位置和人工晶状体性屈光不正预测误差。
Effective lens position and pseudophakic refraction prediction error at 10½ years of age in the Infant Aphakia Treatment Study.
机构信息
Department of Ophthalmology, Harvard Medical School, Boston, Massachsuetts.
Department of Ophthalmology, Naval Medical Center, San Diego, California; School of Medicine, California University of Science and Medicine, San Bernardino, California.
出版信息
J AAPOS. 2022 Aug;26(4):172.e1-172.e5. doi: 10.1016/j.jaapos.2022.04.010. Epub 2022 Jul 20.
BACKGROUND
The refraction prediction error (PE) for infants with intraocular lens (IOL) implantation is large, possibly related to an effective lens position (ELP) that is different than in adult eyes. If these eyes still have nonadult ELPs as they age, this could result in persistently large PE. We aimed to determine whether ELP or biometry at age 10½ years correlated with PE in children enrolled in the Infant Aphakia Treatment Study (IATS).
METHODS
We compared the measured refraction of eyes randomized to primary IOL implantation to the "predicted refraction" calculated by the Holladay 1 formula, based on biometry at age 10½ years. Eyes with incomplete data or IOL exchange were excluded. The PE (predicted - measured refraction) and absolute PE were calculated. Measured anterior chamber depth (ACD) was used to assess the effect of ELP on PE. Multiple regression analysis was performed on absolute PE versus axial length, corneal power, rate of refractive growth, refractive error, and best-corrected visual acuity.
RESULTS
Forty-three eyes were included. The PE was 0.63 ± 1.68 D; median absolute PE, 0.85 D (IQR, 1.83 D). The median absolute PE was greater when the measured ACD was used to calculate predicted refraction instead of the standard A-constant (1.88 D [IQR, 1.72] D vs 0.85 D [IQR, 1.83], resp. [P = 0.03]). Absolute PE was not significantly correlated with any other parameter.
CONCLUSIONS
Variations in ELP did not contribute significantly to PE 10 years after infant cataract surgery.
背景
植入人工晶状体（IOL）的婴儿的屈光度预测误差（PE）较大，这可能与成人眼不同的有效晶状体位置（ELP）有关。如果这些眼睛随着年龄的增长仍然具有非成人 ELP，这可能导致持续较大的 PE。我们旨在确定在婴儿白内障治疗研究（IATS）中入组的儿童中，10 岁半时的 ELP 或生物测量与 PE 是否相关。
方法
我们比较了随机接受 IOL 植入的眼的实际屈光度与基于 10 岁半时生物测量的 Holladay 1 公式计算的“预测屈光度”。排除数据不完整或 IOL 更换的眼。计算了 PE（预测 - 实测屈光度）和绝对 PE。测量了前房深度（ACD）以评估 ELP 对 PE 的影响。对绝对 PE 与眼轴长度、角膜曲率、屈光生长率、屈光不正和最佳矫正视力进行多元回归分析。
结果
共纳入 43 只眼。PE 为 0.63 ± 1.68 D；中位数绝对 PE 为 0.85 D（IQR，1.83 D）。当使用测量的 ACD 计算预测的折射时，中位数绝对 PE 大于标准 A-常数（1.88 D [IQR，1.72] D 与 0.85 D [IQR，1.83]，P = 0.03）。绝对 PE 与其他任何参数均无显著相关性。
结论
婴儿白内障手术后 10 年，ELP 的变化对 PE 的贡献不显著。
Zotero 插件