Lambert Scott R, Cotsonis George, DuBois Lindreth, Wilson M Edward, Plager David A, Buckley Edward G, McClatchey Scott K
From the Department of Ophthalmology (Lambert, DuBois) and the School of Medicine and Biostatistics and Bioinformatics (Cotsonis), Rollins School of Public Health, Emory University, Atlanta, Georgia, the Storm Eye Institute (Wilson), Medical University of South Carolina, Charleston, South Carolina, Glick Eye Institute (Plager), Indiana University, Indianapolis, Indiana, the Department of Ophthalmology, (Buckley), Duke University, Durham, North Carolina, the Department of Ophthalmology, Naval Medical Center, San Diego, and Loma Linda University Medical Center (McClatchey), Loma Linda, California, and the Uniformed Services University of Health Sciences (McClatchey), Bethesda, Maryland, USA.
From the Department of Ophthalmology (Lambert, DuBois) and the School of Medicine and Biostatistics and Bioinformatics (Cotsonis), Rollins School of Public Health, Emory University, Atlanta, Georgia, the Storm Eye Institute (Wilson), Medical University of South Carolina, Charleston, South Carolina, Glick Eye Institute (Plager), Indiana University, Indianapolis, Indiana, the Department of Ophthalmology, (Buckley), Duke University, Durham, North Carolina, the Department of Ophthalmology, Naval Medical Center, San Diego, and Loma Linda University Medical Center (McClatchey), Loma Linda, California, and the Uniformed Services University of Health Sciences (McClatchey), Bethesda, Maryland, USA.
J Cataract Refract Surg. 2016 Dec;42(12):1768-1773. doi: 10.1016/j.jcrs.2016.09.021.
To compare the rate of refractive growth (RRG) between aphakic eyes and pseudophakic eyes in the Infant Aphakia Treatment Study (IATS).
Twelve clinical sites across the United States.
Randomized clinical trial.
Patients randomized to unilateral cataract extraction with contact lens correction versus intraocular lens (IOL) implantation in the IATS had their rate of refractive growth (RRG3) calculated based on the change in refraction from the 1-month postoperative examination to age 5 years. The RRG3 is a logarithmic formula designed to calculate the RRG in children. Two-group t tests were used to compare the mean refractive growth between the contact lens group and IOL group and outcomes based on age at surgery and visual acuity.
Longitudinal refractive data were studied for 108 of 114 patients enrolled in the IATS (contact lens group, n = 54; IOL group, n = 54). The mean RRG3 was similar in the contact lens group (-18.0 diopter [D] ± 11.0 [SD]) and the IOL group (-19.0 ± 9.0 D) (P = .49). The RRG3 value was not correlated with age at cataract surgery, glaucoma status, or visual outcome in the IOL group. In the aphakia group, only visual outcome was correlated with refractive growth (P = .01).
Infants' eyes had a similar rate of refractive growth after unilateral cataract surgery whether or not an IOL was implanted. A worse visual outcome was associated with a higher RRG in aphakic, but not pseudophakic, eyes.
None of the authors has a financial or proprietary interest in any material or method mentioned.
在婴幼儿无晶状体眼治疗研究（IATS）中比较无晶状体眼和人工晶状体眼的屈光增长速率（RRG）。
美国的12个临床地点。
随机临床试验。
在IATS中，随机接受单侧白内障摘除联合角膜接触镜矫正与人工晶状体（IOL）植入的患者，其屈光增长速率（RRG3）根据术后1个月检查至5岁时的屈光变化来计算。RRG3是一个用于计算儿童RRG的对数公式。采用两组t检验比较角膜接触镜组和IOL组之间的平均屈光增长以及基于手术年龄和视力的结果。
对IATS纳入的114例患者中的108例进行了纵向屈光数据研究（角膜接触镜组，n = 54；IOL组，n = 54）。角膜接触镜组（-18.0屈光度[D]±11.0[标准差]）和IOL组（-19.0±9.0 D）的平均RRG3相似（P = 0.49）。IOL组中，RRG3值与白内障手术年龄、青光眼状态或视力结果无关。在无晶状体眼组中，仅视力结果与屈光增长相关（P = 0.01）。
无论是否植入IOL，婴幼儿单侧白内障手术后眼的屈光增长速率相似。在无晶状体眼而非人工晶状体眼中，较差的视力结果与较高的RRG相关。
作者均未对文中提及的任何材料或方法拥有财务或专利权益。
