State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao 999078, China.
Drug Discov Today. 2022 Oct;27(10):103323. doi: 10.1016/j.drudis.2022.07.008. Epub 2022 Jul 20.
Diabetic foot ulcers are one of the most common complications of diabetes, requiring repeated surgical intervention and leading to amputation. Owing to the lack of effective drugs, novel therapeutics need to be explored. Decreased angiogenic factors, endothelial cell dysfunction and vascular lumen stenosis impair angiogenesis in diabetic wounds. Exosome-cargoed microRNAs are emerging as pivotal regulators of angiogenesis during wound closure. Herein, we summarize the up-to-date knowledge of exosomal microRNAs in modulating angiogenesis and accelerating diabetic wound healing, as well as their targets and underlying mechanisms. Exosomal microRNAs could be therapeutics with negligible rejection complications and good compatibility to treat diabetic foot ulcers.
糖尿病足溃疡是糖尿病最常见的并发症之一，需要反复手术干预，最终导致截肢。由于缺乏有效的药物，需要探索新的治疗方法。血管生成因子减少、内皮细胞功能障碍和血管腔狭窄会损害糖尿病创面的血管生成。外泌体携带的 microRNAs 正在成为调控创面闭合过程中血管生成的关键调节因子。本文总结了外泌体 microRNAs 调节血管生成和加速糖尿病创面愈合的最新知识，以及它们的靶点和潜在机制。外泌体 microRNAs 可能是一种治疗方法，具有可忽略的排斥并发症和良好的相容性，可以治疗糖尿病足溃疡。
