Liang Tingting, Liu Jun, Liu Feila, Su Xiaohan, Li Xue, Zeng Jiao, Chen Fuli, Wen Heling, Chen Yu, Tao Jianhong, Lei Qian, Li Gang, Cheng Panke
School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400050, P. R. China.
Department of Breast and thyroid Surgery, Biological Targeting Laboratory of Breast Cancer, Academician (Expert) Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P. R. China.
ACS Omega. 2024 Aug 27;9(36):37505-37529. doi: 10.1021/acsomega.4c04682. eCollection 2024 Sep 10.
Biomaterials have potential applications in the treatment of myocardial infarction (MI). These biomaterials have the ability to mechanically support the ventricular wall and to modulate the inflammatory, metabolic, and local electrophysiological microenvironment. In addition, they can play an equally important role in promoting angiogenesis, which is the primary prerequisite for the treatment of MI. A variety of biomaterials are known to exert pro-angiogenic effects, but the pro-angiogenic mechanisms and functions of different biomaterials are complex and diverse, and have not yet been systematically described. This review will focus on the pro-angiogenesis of biomaterials and systematically describe the mechanisms and functions of different biomaterials in promoting angiogenesis in MI.
生物材料在心肌梗死（MI）治疗中具有潜在应用。这些生物材料能够机械性地支撑心室壁，并调节炎症、代谢和局部电生理微环境。此外，它们在促进血管生成方面可发挥同样重要的作用，而血管生成是MI治疗的首要前提条件。已知多种生物材料具有促血管生成作用，但不同生物材料的促血管生成机制和功能复杂多样，尚未得到系统描述。本综述将聚焦于生物材料的促血管生成作用，并系统描述不同生物材料在促进MI血管生成中的机制和功能。
