Department of Clinical and Health Psychology and Research Methodology; Psychology Faculty, University of the Basque Country (UPV/EHU), Donostia-San Sebastián, Gipuzkoa, Spain.
Department of Clinical and Health Psychology and Research Methodology; Psychology Faculty, University of the Basque Country (UPV/EHU), Donostia-San Sebastián, Gipuzkoa, Spain; Neuroscience Area, Biodonostia Health Research Institute, Donostia-San Sebastián, Gipuzkoa, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Institute Carlos III, Madrid, Spain.
Neuromuscul Disord. 2022 Sep;32(9):749-753. doi: 10.1016/j.nmd.2022.06.012. Epub 2022 Jul 3.
Currently, no rapid and specific instrument is available to briefly estimate intelligence in patients with myotonic dystrophy type 1 (DM1), a multisystemic disease that involves the CNS and is associated with cognitive deficits and low intellectual functioning. This study aimed to develop a DM1-specific and valid short-form of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) to estimate intellectual functioning in this population. Thirty non-congenital DM1 patients (10 female; mean age=46.77; SD= 9.76) were assessed with the WAIS-IV. Data were analyzed following two independent strategies: A) multiple linear regression with the aim of maintaining the scale's factorial structure; and B) correlational analyses between scores on all WAIS-IV subtests and Full-Scale IQ (FSIQ). Validity of the resulting short-forms was also analyzed. Three short-forms were developed: Proposal A from strategy A (Vocabulary, Block Design, Arithmetic and Symbol Search), Proposal B1 (Vocabulary, Block Design, Digit Span and Visual Puzzles) and Proposal B2 (Vocabulary and Block Design), from strategy B. All three short-forms showed a strong and significant correlation with the FSIQ and were considered psychometrically acceptable. Arguments in favor of Proposal B1 are discussed. Assessing FSIQ with these short-forms will be useful for avoiding long assessment procedures in a population characterized by high fatigability.
目前，尚无快速且特定的仪器可用于简要评估 1 型肌强直性营养不良（DM1）患者的智力，这种多系统疾病涉及中枢神经系统，并与认知缺陷和智力低下有关。本研究旨在开发一种针对 DM1 的 Wechsler 成人智力测验第四版（WAIS-IV）简短形式，以评估该人群的智力。30 名非先天性 DM1 患者（10 名女性；平均年龄=46.77；SD=9.76）接受了 WAIS-IV 评估。数据采用两种独立策略进行分析：A）多元线性回归，目的是保持量表的因子结构；B）WAIS-IV 所有子测验分数与全量表智商（FSIQ）之间的相关性分析。还分析了由此产生的简短形式的有效性。开发了三种简短形式：来自策略 A 的提案 A（词汇、积木设计、算术和符号搜索）、提案 B1（词汇、积木设计、数字跨度和视觉拼图）和来自策略 B 的提案 B2（词汇和积木设计）。所有三种简短形式均与 FSIQ 呈强显著相关，被认为具有心理测量学上的可接受性。讨论了赞成提案 B1 的论据。在以高疲劳性为特征的人群中，使用这些简短形式评估 FSIQ 将非常有用。
