Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-rousse, Hospices Civils de Lyon, Lyon, France.
Université Claude Bernard Lyon 1, Villeurbanne, France.
Nat Commun. 2022 Jul 22;13(1):4239. doi: 10.1038/s41467-022-31837-9.
Bone and joint infections (BJI) are one of the most difficult-to-treat bacterial infection, especially in the era of antimicrobial resistance. Lytic bacteriophages (phages for short) are natural viruses that can selectively target and kill bacteria. They are considered to have a high therapeutic potential for the treatment of severe bacterial infections and especially BJI, as they also target biofilms. Here we report on the management of a patient with a pandrug-resistant Pseudomonas aeruginosa spinal abscess who was treated with surgery and a personalized combination of phage therapy that was added to antibiotics. As the infecting P. aeruginosa strain was resistant to the phages developed by private companies that were contacted, we set up a unique European academic collaboration to find, produce and administer a personalized phage cocktail to the patient in due time. After two surgeries, despite bacterial persistence with expression of small colony variants, the patient healed with local and intravenous injections of purified phages as adjuvant therapy.
骨和关节感染（BJI）是最难治疗的细菌感染之一，尤其是在抗微生物药物耐药性的时代。溶菌噬菌体（简称噬菌体）是可以选择性地靶向和杀死细菌的天然病毒。它们被认为具有治疗严重细菌感染的高治疗潜力，特别是 BJI，因为它们也针对生物膜。在这里，我们报告了一例使用噬菌体治疗联合手术治疗泛耐药铜绿假单胞菌脊柱脓肿患者的情况。由于感染的铜绿假单胞菌菌株对联系的私人公司开发的噬菌体具有耐药性，我们建立了一个独特的欧洲学术合作关系，以便及时为患者找到、生产和管理个性化的噬菌体鸡尾酒。尽管两次手术后仍有小菌落变体表达的细菌持续存在，但患者通过局部和静脉注射纯化噬菌体作为辅助治疗而痊愈。
