Narkevich B Ia, Gel'fand I N, Sorokin A I, Averinova S G
Med Radiol (Mosk). 1987 Apr;32(4):48-52.
The task was to develop a simple and effective method of radionuclide determination of separate clearance of the kidneys (SCK), i.e. separate assessment of secretory-excretory function of each kidney. The other earlier known methods of SCK determination were either methodologically incorrect or very difficult. A method of SCK determination intended both for gamma-chambers and standard radiographic units based on common renographic methods, was proposed. An algorithm for processing of measurement results was based on the generalization of the mathematical apparatus of circulation models usually employed for a study of the central and organ hemodynamics, and on its development for transitory nephrotropic radiopharmaceuticals (RP). An investigation of 21 healthy persons and 51 patients with renal tumors using 131I-hippuran showed that the proposed method possessed sufficient sensitivity for its clinical use. Advantages and shortcomings of the method were analysed. All the allowances were justifiable.
任务是开发一种简单有效的放射性核素测定肾脏单独清除率（SCK）的方法，即对每个肾脏的分泌 - 排泄功能进行单独评估。其他先前已知的SCK测定方法要么在方法上不正确，要么非常困难。提出了一种基于普通肾图方法的、适用于γ室和标准放射成像设备的SCK测定方法。测量结果处理算法基于对通常用于研究中心和器官血流动力学的循环模型数学工具的推广，以及对瞬态亲肾放射性药物（RP）的进一步发展。使用131I - 马尿酸对21名健康人和51名肾肿瘤患者进行的研究表明，所提出的方法在临床应用中具有足够的灵敏度。分析了该方法的优缺点。所有的考量都是合理的。
