[Use of a kinetic model of radio-hippuran transport in the human body for the quantitative evaluation of total and divided kidney functions].

The paper is concerned with the results of a method for the interpretation of commonly used methods of the determination of blood clearance and radio-nephrography with 131I-hippuran based on a mathematical model of its transport in the human body. Empirical values of model parameters were obtained in 120 patients with chronic glomerulo- and pyelo-nephritis verified morphologically and roentgenologically. The use of computational-interpretation algorithms made it possible to determine the volume of circulating plasma (blood), values of true summary and isolated effective renal plasma flow (blood flow) by means of a single i. v. hippuran administration. New indicators for assessment of isolated excretory-transport function and renal hemodynamics as well as indicators of the symmetry of renal function were proposed. The results of a statistical analysis made it possible to recommend some of them as criteria of early diagnosis of pre-uremic disorder of renal function. Radionuclide indicators of renal function showed good correlation with biochemical, morphological and roentgenological characteristics of renal damage in renal diseases.