Riabov S I, Degtereva O A, Klemina I K, Degterev B V, Senchik R V
Med Radiol (Mosk). 1986 Apr;31(4):30-4.
The paper is concerned with the results of a method for the interpretation of commonly used methods of the determination of blood clearance and radio-nephrography with 131I-hippuran based on a mathematical model of its transport in the human body. Empirical values of model parameters were obtained in 120 patients with chronic glomerulo- and pyelo-nephritis verified morphologically and roentgenologically. The use of computational-interpretation algorithms made it possible to determine the volume of circulating plasma (blood), values of true summary and isolated effective renal plasma flow (blood flow) by means of a single i. v. hippuran administration. New indicators for assessment of isolated excretory-transport function and renal hemodynamics as well as indicators of the symmetry of renal function were proposed. The results of a statistical analysis made it possible to recommend some of them as criteria of early diagnosis of pre-uremic disorder of renal function. Radionuclide indicators of renal function showed good correlation with biochemical, morphological and roentgenological characteristics of renal damage in renal diseases.
本文基于131I-马尿酸在人体中的转运数学模型，探讨了一种用于解释常用的血液清除率测定方法和放射性肾图的方法的结果。通过对120例经形态学和X射线检查确诊为慢性肾小球肾炎和肾盂肾炎的患者进行研究，获得了模型参数的经验值。利用计算解释算法，通过单次静脉注射马尿酸，能够确定循环血浆（血液）的体积、真正的总有效肾血浆流量（血流）和孤立有效肾血浆流量（血流）的值。提出了评估孤立排泄运输功能和肾血流动力学的新指标以及肾功能对称性指标。统计分析结果使得推荐其中一些指标作为肾功能尿毒症前期紊乱早期诊断的标准成为可能。肾功能的放射性核素指标与肾脏疾病中肾损伤的生化、形态学和X射线特征具有良好的相关性。
