Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
J Med Virol. 2022 Nov;94(11):5163-5173. doi: 10.1002/jmv.28018. Epub 2022 Jul 30.
Viruses as intracellular pathogens take over the host metabolism and reprogram to facilitate optimal virus production. DNA viruses can cause alterations in several metabolic pathways, including aerobic glycolysis also known as the Warburg effect, pentose phosphate pathway activation, and amino acid catabolism such as glutaminolysis, nucleotide biosynthesis, lipid metabolism, and amino acid biosynthesis. The available energy for productive infection can be increased in infected cells via modification of different carbon source utilization. This review discusses the metabolic alterations of the DNA viruses that will be the basis for future novel therapeutic approaches.
病毒作为细胞内病原体接管宿主代谢并重新编程以促进最佳病毒产生。DNA 病毒可引起几种代谢途径的改变，包括有氧糖酵解（也称为瓦博格效应）、磷酸戊糖途径激活和氨基酸分解代谢（如谷氨酰胺分解）、核苷酸生物合成、脂质代谢和氨基酸生物合成。通过改变不同碳源的利用，感染细胞中用于有效感染的可用能量可以增加。本文讨论了 DNA 病毒的代谢改变，这将为未来新的治疗方法奠定基础。
