Wang Hongwei
Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
J Cell Mol Med. 2024 Nov;28(22):e70088. doi: 10.1111/jcmm.70088.
Epstein-Barr virus infection has been implicated in various cancers, including lung cancer, where it influences cellular metabolism to promote tumorigenesis. This review examines the complex interplay between Epstein-Barr virus and cell metabolism in lung cancer, highlighting viral mechanisms of metabolic reprogramming and their implications for therapeutic strategies. Key viral proteins such as LMP1 and LMP2A manipulate glycolysis, glutaminolysis and lipid metabolism to support viral replication and immune evasion within the tumour microenvironment. Understanding these interactions provides insights into novel therapeutic approaches targeting viral-induced metabolic vulnerabilities in Epstein-Barr virus-associated lung cancer.
爱泼斯坦-巴尔病毒感染与包括肺癌在内的多种癌症有关，在肺癌中，它会影响细胞代谢以促进肿瘤发生。本文综述探讨了爱泼斯坦-巴尔病毒与肺癌细胞代谢之间的复杂相互作用，重点介绍了代谢重编程的病毒机制及其对治疗策略的影响。关键病毒蛋白如LMP1和LMP2A操纵糖酵解、谷氨酰胺分解和脂质代谢，以支持病毒在肿瘤微环境中的复制和免疫逃逸。了解这些相互作用有助于深入了解针对爱泼斯坦-巴尔病毒相关肺癌中病毒诱导的代谢脆弱性的新型治疗方法。
