Department of Laboratory, Funan County People's Hospital, Fuyang, China.
Department of Laboratory and Blood Transfusion, Zhuzhou Hospital Affiliated to Xiangya Medical College of Central South University, Zhuzhou, China.
J Clin Lab Anal. 2022 Sep;36(9):e24621. doi: 10.1002/jcla.24621. Epub 2022 Jul 23.
To evaluate the prediction and effect of fibrinogen-to-albumin ratio (FAR) on active, severe active, and poor prognosis of systemic lupus erythematosus (SLE).
One hundred and sixty-eight patients with SLE who were treated in our hospital were enrolled, the clinical data, laboratory indexes, and disease prognosis of all patients were collected and analyzed.
Triglyceride (TG), FAR, ESR, and anti-dsDNA (+) were the influencing factors, while complement 3 (C3) was the protective factor of active SLE, the odds ratio (OR) values were 2.968, 3.698, 2.114, 2.727, and 0.652, respectively (p < 0.05). FAR, ESR, and anti-dsDNA (+) were the influencing factors, while C3 was the protective factor of severe active SLE, the OR values were 3.791, 1.953, 2.187, and 0.742, respectively (p < 0.05). SLE disease activity index (SLEDAI), TG, FAR, and anti-dsDNA (+) were the influencing factors, while C3 was the protective factor of poor prognosis SLE, the OR values were 3.024, 2.293, 3.012, 2.323, and 0.801, respectively (p < 0.05). FAR and FIB were positively correlated with SLEDAI, while ALB was negatively correlated with SLEDAI, the related coefficient (r) were 0.398, 0.267, -0.270, respectively. The receiver operating curve (ROC) analysis showed that the predictive values of FAR for active, severe active and poor prognosis SLE were 0.769, 0.769, and 0.734, respectively, were significant higher than FIB and ALB (p < 0.05).
Fibrinogen-to-albumin ratio was an influencing factor of active, severe active, and poor prognosis SLE had higher predictive value than FIB and ALB for the activity and prognosis of SLE.
评估纤维蛋白原与白蛋白比值（FAR）对系统性红斑狼疮（SLE）活动、重度活动和预后不良的预测和影响。
选取我院收治的 168 例 SLE 患者，收集并分析所有患者的临床资料、实验室指标及疾病预后。
甘油三酯（TG）、FAR、红细胞沉降率（ESR）和抗双链 DNA（+）是活动 SLE 的影响因素，而补体 3（C3）是活动 SLE 的保护因素，其比值比（OR）值分别为 2.968、3.698、2.114、2.727 和 0.652（p<0.05）。FAR、ESR 和抗双链 DNA（+）是重度活动 SLE 的影响因素，而 C3 是重度活动 SLE 的保护因素，OR 值分别为 3.791、1.953、2.187 和 0.742（p<0.05）。SLE 疾病活动指数（SLEDAI）、TG、FAR 和抗双链 DNA（+）是预后不良 SLE 的影响因素，而 C3 是预后不良 SLE 的保护因素，OR 值分别为 3.024、2.293、3.012、2.323 和 0.801（p<0.05）。FAR 和 FIB 与 SLEDAI 呈正相关，ALB 与 SLEDAI 呈负相关，相关系数（r）分别为 0.398、0.267、-0.270。受试者工作特征曲线（ROC）分析显示，FAR 对活动、重度活动和预后不良 SLE 的预测值分别为 0.769、0.769 和 0.734，均显著高于 FIB 和 ALB（p<0.05）。
纤维蛋白原与白蛋白比值是活动、重度活动和预后不良 SLE 的影响因素，对 SLE 的活动和预后具有较高的预测价值，优于 FIB 和 ALB。
