在晚期视网膜色素变性中，全视野刺激阈值与功能和解剖学结果测量的相关性。
Correlations of Full-Field Stimulus Threshold With Functional and Anatomical Outcome Measurements in Advanced Retinitis Pigmentosa.
机构信息
From the Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA; Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology, Columbia University, New York, New York, USA; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
From the Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA; Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology, Columbia University, New York, New York, USA.
出版信息
Am J Ophthalmol. 2023 Jan;245:155-163. doi: 10.1016/j.ajo.2022.07.010. Epub 2022 Jul 20.
PURPOSE
To compare full-field stimulus (FST) threshold values to conventional functional and anatomical measures commonly used in clinical practice.
DESIGN
Cross-sectional study.
METHODS
Patients with retinitis pigmentosa with nondetectable electroretinogram rod-mediated responses and light-adapted 3.0 cd·s·m 30-Hz flicker (LA 3.0 flicker) amplitudes of 15 mV or less were included in this study. The threshold values for blue, white, and red stimuli on FST were correlated with best-corrected visual acuity, LA 3.0 flicker amplitude and implicit times, length of the ellipsoid zone (EZ) band and thickness of outer nuclear layer measurements on optical coherence tomography, and the vertical and horizontal diameters of the autofluorescent ring on autofluorescence imaging.
RESULTS
Forty-two eyes of 21 patients were included in the study. The mean FST thresholds were -22.5 ± 15.5 dB, -17.6 ± 11.5 dB, and -12.7 ± 6.0 dB for the blue, white, and red stimuli, respectively. The threshold values for the 3 FST stimuli were significantly correlated with selected functional and anatomical outcome measures. Specifically, they were strongly correlated with LA 3.0 flicker amplitude and EZ band length measured on optical coherence tomography. Using linear regression, blue and white stimulus values on FST were found to be predictive of EZ band length (R = 0.579 and 0.491, respectively), and the vertical (R = 0.694 and 0.532, respectively) and horizontal (R = 0.626 and 0.400, respectively) diameters of the hyperautofluorescent ring.
CONCLUSIONS
The significant correlations between FST and other clinical outcome measures highlight its potential as an adjunct outcome measure.
目的
比较全视野刺激（FST）阈值与临床实践中常用的常规功能和解剖学测量值。
设计
横断面研究。
方法
本研究纳入了视网膜色素变性患者，这些患者的视网膜电图杆状反应无法检测，且光适应 3.0 cd·s·m-30 Hz 闪烁（LA 3.0 闪烁）幅度小于 15 mV。FST 蓝色、白色和红色刺激的阈值与最佳矫正视力、LA 3.0 闪烁幅度和潜伏期、光相干断层扫描上的椭圆体带长度和外核层厚度以及自发荧光成像上的自发荧光环的垂直和水平直径相关。
结果
21 例患者的 42 只眼纳入本研究。蓝色、白色和红色刺激的平均 FST 阈值分别为-22.5 ± 15.5 dB、-17.6 ± 11.5 dB 和-12.7 ± 6.0 dB。3 种 FST 刺激的阈值与选定的功能和解剖学结果测量值显著相关。具体而言，它们与光相干断层扫描上测量的 LA 3.0 闪烁幅度和椭圆体带长度密切相关。使用线性回归，FST 上的蓝色和白色刺激值被发现可以预测椭圆体带长度（R2 分别为 0.579 和 0.491），以及超荧光环的垂直（R2 分别为 0.694 和 0.532）和水平（R2 分别为 0.626 和 0.400）直径。
结论
FST 与其他临床结果测量值之间的显著相关性突出了其作为辅助结果测量值的潜力。
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