Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, ,Tehran, Iran.
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Curr Probl Cardiol. 2022 Nov;47(11):101336. doi: 10.1016/j.cpcardiol.2022.101336. Epub 2022 Jul 20.
The impact of Algae supplements and its extract on blood pressure has not concluded yet. The aim of this systematic review meta-analysis is to evaluate the antihypertensive activity of this group marine organism on human. Alga was used in some studies as capsules (from 500-mg to 8-g) and the follow-up duration changed from 17 days to 9 months. The difference in standardized mean and its corresponding 95% confidence interval (CI) was applied as the effect size of algae supplementation on systolic and diastolic blood pressure. Based on the results, a meta-analysis of 10 studies with baseline effect control demonstrated that there was no difference in the mean systolic blood pressure in the 2 groups SMD (95%CI): -1.05 (-2.85,0.76), but a significant difference in the mean diastolic blood pressure was observed and showed that the mean diastolic blood pressure in the treatment group was lower than the control group SMD(95%CI): -2.23 (-4.35,-0.11). A meta-analysis of 4 studies with no baseline control effect did not show significant results on both blood pressure. The evidence to support this systematic review meta-analysis requires more investigation and future large scale RCT clinical trial to confirm the results.
藻类补充剂及其提取物对血压的影响尚未得出结论。本系统评价荟萃分析的目的是评估这组海洋生物对人类的降压活性。在一些研究中，藻类被用作胶囊（500mg 至 8g），随访时间从 17 天到 9 个月不等。标准化均值及其相应的 95%置信区间（CI）的差异被用作藻类补充剂对收缩压和舒张压的效应大小。基于这些结果，对 10 项具有基线效应控制的研究进行荟萃分析表明，两组收缩压的平均差异无统计学意义 SMD（95%CI）：-1.05（-2.85，0.76），但舒张压的平均差异有统计学意义，表明治疗组的舒张压低于对照组 SMD（95%CI）：-2.23（-4.35，-0.11）。对 4 项无基线对照效果的研究进行荟萃分析，对血压均未显示出显著结果。支持本系统评价荟萃分析的证据需要进一步调查和未来的大规模 RCT 临床试验来证实结果。
