Oxford Centre for Computational Neuroscience, Oxford, UK; University of Warwick, Department of Computer Science, Coventry, UK.
Prog Neurobiol. 2022 Oct;217:102334. doi: 10.1016/j.pneurobio.2022.102334. Epub 2022 Jul 21.
The human ventromedial prefrontal cortex (vmPFC)/anterior cingulate cortex is implicated in reward and emotion, but also in memory. It is shown how the human orbitofrontal cortex connecting with the vmPFC and anterior cingulate cortex provide a route to the hippocampus for reward and emotional value to be incorporated into episodic memory, enabling memory of where a reward was seen. It is proposed that this value component results in primarily episodic memories with some value component to be repeatedly recalled from the hippocampus so that they are more likely to become incorporated into neocortical semantic and autobiographical memories. The same orbitofrontal and anterior cingulate regions also connect in humans to the septal and basal forebrain cholinergic nuclei, thereby helping to consolidate memory, and helping to account for why damage to the vMPFC impairs memory. The human hippocampus and vmPFC thus contribute in complementary ways to forming episodic and semantic memories.
人类腹内侧前额叶皮层（vmPFC）/前扣带皮层与奖赏和情绪有关，但也与记忆有关。研究表明，人类眶额皮层与 vmPFC 和前扣带皮层的连接为奖赏和情感价值进入情景记忆提供了一条途径，使记忆能够记住在哪里看到了奖励。有人提出，这种价值成分主要导致情景记忆，其中一些价值成分会从海马体中反复回忆，从而更有可能被纳入新皮层的语义和自传体记忆。人类的眶额皮层和前扣带皮层也与隔核和基底前脑胆碱能核相连，从而有助于巩固记忆，并有助于解释为什么 vmPFC 的损伤会损害记忆。因此，人类的海马体和 vmPFC 以互补的方式有助于形成情景记忆和语义记忆。
