Wang Yue, Cao Runnan, Willie Jon T, Brunner Peter, Wang Shuo
Department of Radiology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Sci Data. 2025 Aug 25;12(1):1482. doi: 10.1038/s41597-025-05839-3.
Understanding linguistic and semantic processing in the human brain involves exploring intricate neural networks. However, it remains unclear whether and how the amygdala and hippocampus are involved in these processes. Here, we recorded single-neuron activity from the human amygdala and hippocampus while neurosurgical patients with intractable epilepsy performed various language tasks. Specifically, we recorded from 68 neurons in 7 patients for the visual language localizer task, 115 neurons in 12 patients for the auditory language localizer task, 88 neurons in 9 patients for the TIMIT task, and 51 neurons in 4 patients for the natural story task. Together, our comprehensive dataset with a considerable population of neurons can facilitate multifaceted investigation of language and semantic processing with the highest spatial and temporal resolution currently available in humans.
了解人类大脑中的语言和语义处理涉及探索复杂的神经网络。然而，杏仁核和海马体是否以及如何参与这些过程仍不清楚。在这里，我们记录了患有顽固性癫痫的神经外科患者在执行各种语言任务时杏仁核和海马体的单神经元活动。具体来说，我们在7名患者的68个神经元上记录了视觉语言定位任务的数据，在12名患者的115个神经元上记录了听觉语言定位任务的数据，在9名患者的88个神经元上记录了TIMIT任务的数据，在4名患者的51个神经元上记录了自然故事任务的数据。总之，我们拥有大量神经元的综合数据集能够以目前人类可获得的最高空间和时间分辨率促进对语言和语义处理的多方面研究。
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