Cobaleda Cesar, Vicente-Dueñas Carolina, Ramírez-Orellana Manuel, Sanchez-Garcia Isidro
Immune system development and function Unit, Centro de Biología Molecular Severo Ochoa (CSIC -Universidad Autónoma de Madrid), Madrid, Spain.
Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Trends Cancer. 2022 Nov;8(11):887-889. doi: 10.1016/j.trecan.2022.06.012. Epub 2022 Jul 21.
Preleukemic has been used to describe children with a propensity to develop B cell acute lymphoblastic leukemia (B-ALL). However, leukemia-predisposing mutations can also be present in differentiated cells unable to transform. We postulate that preleukemia should only be used when such mutations arise in progenitors capable of evolving to B-ALL.
白血病前期曾被用于描述有发展为B细胞急性淋巴细胞白血病（B-ALL）倾向的儿童。然而，白血病易感突变也可能存在于无法转化的分化细胞中。我们推测，只有当此类突变出现在能够演变为B-ALL的祖细胞中时，才应使用白血病前期这一术语。
