Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, South Korea.
Dermatol Ther. 2022 Sep;35(9):e15732. doi: 10.1111/dth.15732. Epub 2022 Aug 2.
Microneedling is a common cosmetic procedure for improvement of wrinkles, acne, scars, and other conditions. Various microneedle (MN) patches have been developed as home care therapy for wrinkles and skin texture. Most of them are made of soluble and absorbable needles. To evaluate the efficacy and safety of non-absorbable magnesium (Mg) MN patches on under-eye wrinkles. A total of 20 subjects aged 27-58 years was enrolled in the study. The subjects applied Mg MN patches on the under-eye wrinkle area for 1-2 h every other night for 12 weeks. The evaluation comprised grading by clinicians, measuring the wrinkle index with a facial analyzer, and measuring the dermal thickness of the under-eye area with ultrasonography. Any adverse events and discomfort were addressed during the study. The application of Mg MN patches on under-eye areas showed improvements in under-eye grading scale, wrinkle index, and dermal thickness after 12 weeks. The mean grading scale significantly improved after 8 weeks of application (p < 0.01). The wrinkle index showed significant improvement after 12 weeks on the right under-eye area (p < 0.05). The dermal thickness of the under-eye area tended to increase, but no statistically significant changes were observed. Non-absorbable Mg MN patches can be used for under-eye wrinkles with minimal discomfort.
微针是一种常见的美容程序，用于改善皱纹、痤疮、疤痕和其他状况。各种微针（MN）贴片已被开发为皱纹和皮肤纹理的家庭护理疗法。它们大多由可溶解和可吸收的针制成。为评估非吸收性镁（Mg）MN 贴片对眼周皱纹的疗效和安全性，共招募了 20 名 27-58 岁的受试者。受试者每两天晚上在眼周皱纹区域使用 Mg MN 贴片 1-2 小时，持续 12 周。评估包括临床医生分级、使用面部分析仪测量皱纹指数以及使用超声测量眼周区域的真皮厚度。在研究过程中，对任何不良反应和不适进行了评估。Mg MN 贴片在眼周区域的应用显示，在 12 周后，眼周分级量表、皱纹指数和眼周真皮厚度均有所改善。应用 8 周后，平均分级量表显著改善（p<0.01）。右眼周的皱纹指数在 12 周后显著改善（p<0.05）。眼周真皮厚度有增加的趋势，但无统计学意义。非吸收性 Mg MN 贴片可用于眼周皱纹，且不适感最小。
