Department of Biological Sciences, Birla Institute of Technology and Science, Pilani-Hyderabad Campus, Jawahar Nagar, Hyderabad, 500 078, India.
Mol Biol Rep. 2022 Nov;49(11):10825-10847. doi: 10.1007/s11033-022-07770-x. Epub 2022 Jul 24.
Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer-related death worldwide. Despite aggressive treatment approaches, the recurrence of HNSCC remains a challenge. Cytokines play an essential role in HNSCC development and progression. They are not only involved in promoting cancer growth but may also be involved in an anti-tumor immune response. Non-coding RNAs (ncRNAs) have emerged as important transcriptional and post-transcriptional mediators of cytokine function in HNSCC. This review focuses on the complex regulatory network among regulatory ncRNAs and cytokines during HNSCC pathogenesis.
头颈部鳞状细胞癌（HNSCC）是全球癌症相关死亡的主要原因。尽管采用了积极的治疗方法，但 HNSCC 的复发仍然是一个挑战。细胞因子在 HNSCC 的发生和发展中起着至关重要的作用。它们不仅参与促进癌症生长，还可能参与抗肿瘤免疫反应。非编码 RNA（ncRNA）已成为 HNSCC 中细胞因子功能的重要转录和转录后调节因子。本综述重点介绍了 HNSCC 发病机制中调节性 ncRNA 和细胞因子之间复杂的调控网络。
