Wang Ze-Kun, Xu Xin, Zhou Xue-Dong
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Dental and Endodontic Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 Jul;53(4):732-736. doi: 10.12182/20220760108.
Cardiovascular disease (CVD) is a major cause of death worldwide. Research findings indicate that periodontal infection is an independent risk factor for CVD. Periodontal pathogens can cause cardiovascular diseases through various pathways, including direct invasion, induction of platelet activation and agglutination, immune inflammatory response, bacteremia, and oxidative stress. Moreover, CVD symptoms are relieved after the patients undergo periodontal interventional treatment. There have been substantial findings indicating that there may be a close connection between periodontal disease and CVD. However, periodontal disease is a chronic disease. The treatment of periodontal diseases and the improvement of periodontal health require long-term efforts. Long-term effective reduction of the incidence of CVD in clinical practice through prevention of periodontal disease remains a challenging area of study. Here we summarized and reported the latest findings on the mechanism of action of periodontal pathogens in cardiovascular diseases, intending to contribute to the better understanding of the pathogenesis of CVD and to provide potential targets and new ideas for its prevention and treatment.
心血管疾病（CVD）是全球主要的死亡原因。研究结果表明，牙周感染是心血管疾病的独立危险因素。牙周病原体可通过多种途径引发心血管疾病，包括直接侵袭、诱导血小板活化和凝集、免疫炎症反应、菌血症和氧化应激。此外，患者接受牙周介入治疗后，心血管疾病症状会得到缓解。已有大量研究结果表明，牙周病与心血管疾病之间可能存在密切联系。然而，牙周病是一种慢性病。牙周病的治疗和牙周健康的改善需要长期努力。通过预防牙周病在临床实践中长期有效降低心血管疾病的发病率仍然是一个具有挑战性的研究领域。在此，我们总结并报告了牙周病原体在心血管疾病中作用机制的最新研究结果，旨在有助于更好地理解心血管疾病的发病机制，并为其预防和治疗提供潜在靶点和新思路。
