University of California, San Francisco, San Francisco, California, USA.
City University of Hong Kong, Kowloon, Hong Kong.
Am J Transplant. 2022 Dec;22(12):2912-2920. doi: 10.1111/ajt.17159. Epub 2022 Aug 3.
Since the introduction of the MELD-based allocation system, women are now 30% less likely than men to undergo liver transplant (LT) and have 20% higher waitlist mortality. These disparities are in large part due to height differences in men and women though no national policies have been implemented to reduce sex disparities. Patients were identified using the Scientific Registry of Transplant Recipients (SRTR) from 2014 to 2019. Patients were categorized into five groups by first dividing into thirds by height then dividing the shortest third into three groups to capture more granular differences in the most disadvantaged patients (<166 cm). We then used LSAM to model waitlist outcomes in five versions of awarding additional MELD points to shorter candidates compared to current policy. We identified two proposed policy changes LSAM scenarios that resulted in improvement in LT and death percentage for the shortest candidates with the least negative impact on taller candidates. In conclusion, awarding an additional 1-2 MELD points to the shortest 8% of LT candidates would improve waitlist outcomes for women. This strategy should be considered in national policy allocation to address sex-based disparities in LT.
自 MELD 为基础的分配系统引入以来,女性接受肝移植 (LT) 的可能性比男性低 30%,而在等待名单上的死亡率则高 20%。这些差异在很大程度上归因于男女身高的差异,尽管没有实施任何国家政策来减少性别差异。
患者是通过 2014 年至 2019 年的科学移植受者登记处 (SRTR) 确定的。患者首先按身高分为三分之一,然后将最短的三分之一分为三组,以捕捉最弱势患者(<166cm)更细微的差异。然后,我们使用 LSAM 在与当前政策相比为更矮小的候选人额外增加 1-2 个 MELD 点的五个版本中,对等待名单的结果进行建模。我们确定了两种拟议的政策变化 LSAM 情景,这些情景导致对最短候选人的 LT 和死亡百分比有所改善,而对更高候选人的负面影响最小。
总之,为最短的 8%LT 候选人额外增加 1-2 个 MELD 点将改善女性的等待名单结果。在国家政策分配中,应考虑这一策略,以解决 LT 中的性别差异问题。