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肝移植中的公平性:我们更接近目标了吗?

Equity in liver transplantation: are we any closer?

作者信息

Ogundolie Moronke, Chan Norine, McElroy Lisa M

机构信息

Duke University School of Medicine, Durham, North Carolina, USA.

出版信息

Curr Opin Organ Transplant. 2023 Aug 1;28(4):259-264. doi: 10.1097/MOT.0000000000001085. Epub 2023 Jun 19.

Abstract

PURPOSE OF REVIEW

As policies governing liver transplantation (LT) continue to change and influence clinical practice, it is important to monitor trends in equitable access and outcomes amongst patients. The purpose of this review is to closely examine recent advances and findings in health equity research in LT over the last 2 years; specifically evaluating inequities at the different stages of LT (referral, evaluation, listing, waitlist outcomes and post-LT outcomes).

RECENT FINDINGS

Advancements in geospatial analysis have enabled investigators to identify and begin to study the role of community level factors (such as neighborhood poverty, increased community capital/urbanicity score) in driving LT disparities. There has also been a shift in investigating center specific characteristics that contributes to disparities in waitlist access. Modification to the current model for end stage liver disease (MELD) score policy accounting for height differences is also crucial to eradicating the disparity in LT amongst sexes. Lastly, Black pediatric patients have been shown to have higher rates of death and worse posttransplant outcome after transitioning to adult healthcare.

SUMMARY

Although, there have been some advances in methodology and policies, inequities in waitlist access, waitlist outcomes and posttransplant outcomes continue to be pervasive in the field of LT. Future directions include expansion of social determinants of health measures, inclusion of multicenter designs, MELD score modification and investigation into drivers of worse posttransplant outcomes in Black patients.

摘要

综述目的

随着肝移植(LT)相关政策不断变化并影响临床实践,监测患者公平获取肝移植及肝移植结局的趋势至关重要。本综述旨在深入研究过去两年肝移植健康公平性研究的最新进展和发现;具体评估肝移植不同阶段(转诊、评估、列入名单、等待名单结局及肝移植后结局)的不公平现象。

最新发现

地理空间分析的进展使研究人员能够识别并开始研究社区层面因素(如邻里贫困、社区资本/城市化得分增加)在导致肝移植差异方面的作用。在调查导致等待名单获取差异的特定中心特征方面也有转变。修改当前的终末期肝病模型(MELD)评分政策以考虑身高差异对于消除性别间肝移植差异也至关重要。最后,研究表明,黑人儿科患者在转至成人医疗保健后死亡率更高,移植后结局更差。

总结

尽管在方法和政策方面取得了一些进展,但在肝移植领域,等待名单获取、等待名单结局及移植后结局方面的不公平现象仍然普遍存在。未来的方向包括扩大健康的社会决定因素测量范围、纳入多中心设计、修改MELD评分以及调查黑人患者移植后结局较差的驱动因素。

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