Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland; BioMag Laboratory, HUS Diagnostic Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
J Neurosci Methods. 2022 Oct 1;380:109677. doi: 10.1016/j.jneumeth.2022.109677. Epub 2022 Jul 21.
Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) allows measuring non-invasively the electrical response of the human cerebral cortex to a direct perturbation. Complementing TMS-EEG with a structural neuronavigation tool (nTMS-EEG) is key for accurately selecting cortical areas, targeting them, and adjusting the stimulation parameters based on some relevant anatomical priors. This step, together with the employment of visualization tools designed to perform a quality check of TMS-evoked potentials (TEPs) in real-time during TMS-EEG data acquisition, is pivotal for maximizing the impact of the TMS pulse on the cortex and in ensuring highly reproducible measurements within sessions and across subjects. Moreover, storing stimulation parameters in the neuronavigation system can help in replicating the stimulation parameters within and across experimental sessions and sharing them across research centers. Finally, the systematic employment of neuronavigation in TMS-EEG studies is also critical to standardize measurements in clinical populations in search for reliable diagnostic and prognostic TMS-EEG-based biomarkers for neurological and psychiatric disorders.
经颅磁刺激结合脑电图（TMS-EEG）允许非侵入性地测量人类大脑皮层对直接干扰的电反应。将结构神经导航工具（nTMS-EEG）与 TMS-EEG 相结合对于准确选择皮质区域、靶向它们以及根据一些相关的解剖学先验来调整刺激参数至关重要。这一步，以及使用旨在在 TMS-EEG 数据采集过程中实时执行 TMS 诱发电位（TEP）质量检查的可视化工具，对于最大限度地提高 TMS 脉冲对皮层的影响以及确保在会话内和跨受试者内进行高度可重复的测量至关重要。此外，将刺激参数存储在神经导航系统中有助于在实验会话内和跨实验会话复制刺激参数，并在研究中心之间共享。最后，在 TMS-EEG 研究中系统地使用神经导航对于在神经和精神障碍的可靠诊断和预后 TMS-EEG 生物标志物的临床人群中标准化测量也是至关重要的。
