State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China.
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, 330004, PR China.
J Ethnopharmacol. 2022 Oct 28;297:115522. doi: 10.1016/j.jep.2022.115522. Epub 2022 Jul 22.
In recent years, there are increasing that the number of patients with psoriasis day by day, and it has become a common disease endangering public health. However, there is no specific cure for psoriasis or control of recurrence. Therefore, it's necessity to seek alternative and efficient therapy, such as Traditional Chinese Medicine (TCM). As a TCM and effective medicine for the treatment of psoriasis, Indigo Naturalis (Baphicacanthus Cusia (Nees) Bremek.) has the effect of clearing heat, detoxifying blood, eliminating spots, reducing fire and calming panic, and it is used in many classical prescriptions for the treatment of psoriasis.
To review the latest progress and strategies of Indigo Naturalis in the treatment of psoriasis. This manuscript mainly clarifies the traditional medicinal applications, the mechanism of action and application strategies of Indigo Naturalis, and its preparations in the treatment of psoriasis.
Detailed information on Indigo Naturalis was collected from various online databases (PubMed, GeenMedical, Web of Science, Google Scholar, China National Knowledge Infrastructure Database, and National Intellectual Property Administration).
This manuscript reviews a great deal of information about how Indigo Naturalis can treat psoriasis through immune cells, signal pathways and disease-related mediators. The mechanism of cymbididae is expounded from the aspects of regulating keratinocyte proliferation and differentiation, regulating inflammatory infiltration of cellular immune system and improving microvascular dilation and hyperplasia in skin lesions.
The action mechanisms of Indigo Naturalis on psoriasis reflect the characteristics of multiple components, multiple targets, and multiple pathways of Traditional Chinese medicine. However, some pharmacological and clinical research methods are improper, so that the results are difficult to explain at present. Therefore, further in-depth research is needed to provide knowledge in a wider range of areas to confirm the great therapeutic potential of Indigo Naturalis.
近年来，银屑病患者的数量日益增加，已成为危害公众健康的常见疾病。然而，目前尚无针对银屑病的特定治疗方法或控制其复发的方法。因此，寻求替代和有效的治疗方法，如中药（TCM），是必要的。作为一种治疗银屑病的中药和有效药物，青黛具有清热、解毒、祛斑、降火、镇静的功效，被许多经典方剂用于治疗银屑病。
综述青黛治疗银屑病的最新进展和策略。本文主要阐明了青黛在治疗银屑病中的传统药用应用、作用机制和应用策略，以及其制剂。
从各种在线数据库（PubMed、GeenMedical、Web of Science、Google Scholar、中国国家知识基础设施数据库和国家知识产权局）收集有关青黛的详细信息。
本文综述了青黛如何通过免疫细胞、信号通路和与疾病相关的介质来治疗银屑病的大量信息。从调节角质形成细胞增殖和分化、调节细胞免疫系统的炎症浸润以及改善皮肤病变中的微血管扩张和增生等方面阐述了青黛的作用机制。
青黛对银屑病的作用机制反映了中药多成分、多靶点、多途径的特点。然而，一些药理学和临床研究方法不恰当，使得目前的结果难以解释。因此，需要进一步深入研究，以提供更广泛领域的知识，从而确认青黛的巨大治疗潜力。
